ReferenceID 722
Brown marine algae Gongolaria baccata extract protects Caco-2 cells from oxidative stress induced by tert-butyl hydroperoxide
Food Chem Toxicol
Gongolaria baccata (S.G. Gmelin) is marine brown seaweed mainly found on the coasts of the Baltic Sea south to the Mediterranean Sea, Canary Islands, Mauritania and Western Sahara. Herein, we report the cell viability an
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Record Fields
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- Reference Id
- 722
- Evidence Id
- 17312
- Core Evidence Id
- 17312
- Source Reference Id
- 1439
- Herb2 Reference Id
- HBREF002236
- Subject Paper Key
- HERB002126_34348126
- Pubmed Id
- 34348126
- Doi
- 10.1016/j.fct.2021.112460
- Paper Title
- Brown marine algae Gongolaria baccata extract protects Caco-2 cells from oxidative stress induced by tert-butyl hydroperoxide
- Paper Abstract
- Gongolaria baccata (S.G. Gmelin) is marine brown seaweed mainly found on the coasts of the Baltic Sea south to the Mediterranean Sea, Canary Islands, Mauritania and Western Sahara. Herein, we report the cell viability and protective effects attributed to molecular mechanisms underlying antioxidant response to survive oxidative stress injuries. Caco-2 cells were submitted to oxidative stress by treatment with tert-butylhydroperoxide (tert-BOOH). The extract prevented cell damage and enhanced activity of antioxidant defenses (NQO1 and GST activities and GSH levels) reduced by treatment with tert-BOOH. The increases of MDA levels, the amount of intracellular ROS and caspase 3/7 activity induced by tert-BOOH were prevented when cells were treated with the G. baccata extract. Moreover, G. baccata extract caused up-regulation of GSTM2, Nrf2, and AKT1 gene expressions, as well as G. baccata extract reduced significantly Bax, BNIP3, APAF1, ERK1, JNK1, MAPK1, P38, P53, NFkappaB1, TNFalpha, IL-6, IL-1beta and HO-1 gene expressions related to apoptosis, proinflammation and oxidative stress induced by tert-BOOH. These results suggest that G.baccata extract protected the cells against oxidative damage and inflammation; protective effects that could be linked to their bioactive constituents. Hence, this brown seaweed G.baccata extract could be used for the development of functional foods and/or nutraceuticals.
- Journal
- Food Chem Toxicol
- Publish Year
- 2021
- Experiment Subject
- caco-2 cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Gongolaria Baccata; Oxidative Stress Injuries; Inflammation
- Paper Title Cn
- Paper Title En
- Brown marine algae Gongolaria baccata extract protects Caco-2 cells from oxidative stress induced by tert-butyl hydroperoxide
- Bilingual Status
- semi_complete