ReferenceID 720
Sargassum horneri as a Functional Food Ameliorated IgE/BSA-Induced Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice
Mar Drugs
Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an eth
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- Reference Id
- 720
- Evidence Id
- 17310
- Core Evidence Id
- 17310
- Source Reference Id
- 1435
- Herb2 Reference Id
- HBREF002232
- Subject Paper Key
- HERB002126_33256200
- Pubmed Id
- 33256200
- Doi
- 10.3390/md18120594
- Paper Title
- Sargassum horneri as a Functional Food Ameliorated IgE/BSA-Induced Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice
- Paper Abstract
- Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin E (IgE)/bovine serum albumin (BSA)-mediated activation in bone marrow-derived cultured-mast cells (BMCMCs) and passive cutaneous anaphylaxis (PCA) reaction in mice. SHE markedly and dose-dependently suppressed the degranulation of BMCMCs by reducing the beta-hexosaminidase and histamine release without cytotoxicity. In addition, SHE significantly decreased the FcepsilonRI expression on the surface of BMCMCs and its IgE binding. Moreover, SHE reduced the mRNA expression and the production of allergic cytokines; interleukin (IL)-1beta, IL-4, IL-5, IL-6, IL-10, IL-13; interferon (IFN)-gamma and/or tumor necrosis factor (TNF)-alpha; and a chemokine, thymus and activation-regulated chemokine (TARC), by suppressing the activation of Src-family kinases and nuclear factor (NF)-kappaB signaling. In further study, the application of SHE reduced the PCA reaction in an IgE/BSA-induced type I allergic mice model. Taken together, we suggest that SHE has an anti-allergic effect in type I allergic responses.
- Journal
- Mar Drugs
- Publish Year
- 2020
- Experiment Subject
- mouse; bone marrow-derived cultured-mast cells; bovine
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Type I Allergic Responses; Tumor; Sargassum Horneri; Cutaneous Anaphylaxis
- Paper Title Cn
- Paper Title En
- Sargassum horneri as a Functional Food Ameliorated IgE/BSA-Induced Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice
- Bilingual Status
- semi_complete