ReferenceID 697
Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice
Allergol Int
BACKGROUND: Propolis is a resinous mixture produced by honey bees that contains cinnamic acid derivatives and flavonoids. Although propolis has been reported to inhibit mast cell functions and mast cell-dependent allergi
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- Reference Id
- 697
- Evidence Id
- 17287
- Core Evidence Id
- 17287
- Source Reference Id
- 1379
- Herb2 Reference Id
- HBREF002176
- Subject Paper Key
- HERB001705_33279402
- Pubmed Id
- 33279402
- Doi
- 10.1016/j.alit.2020.11.005
- Paper Title
- Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice
- Paper Abstract
- BACKGROUND: Propolis is a resinous mixture produced by honey bees that contains cinnamic acid derivatives and flavonoids. Although propolis has been reported to inhibit mast cell functions and mast cell-dependent allergic responses, the effect of propolis on basophil biology remains unknown. This study aimed to investigate the inhibitory effect of propolis on FcepsilonRI-mediated basophil activation. METHODS: To determine the inhibitory effect of propolis on basophil activation in vitro, cytokine production and FcepsilonRI signal transduction were analyzed by ELISA and western blotting, respectively. To investigate the inhibitory effect of propolis in vivo, IgE-CAI and a food allergy mouse model were employed. RESULTS: Propolis treatment resulted in the suppression of IgE/antigen-induced production of IL-4, IL-6 and IL-13 in basophils. Phosphorylation of FcepsilonRI signaling molecules Lyn, Akt and ERK was inhibited in basophils treated with propolis. While propolis did not affect the basophil population in the treated mice, propolis did inhibit IgE-CAI. Finally, ovalbumin-induced intestinal anaphylaxis, which involves basophils and basophil-derived IL-4, was attenuated in mice prophylactically treated with propolis. CONCLUSIONS: Taken together, these results demonstrate the ability of propolis to suppress IgE-dependent basophil activation and basophil-dependent allergic inflammation. Therefore, prophylactic treatment with propolis may be useful for protection against food allergic reactions in sensitive individuals.
- Journal
- Allergol Int
- Publish Year
- 2021
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Basophil-dependent Allergic Inflammation; Ovalbumin-induced Intestinal Anaphylaxis
- Paper Title Cn
- Paper Title En
- Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice
- Bilingual Status
- semi_complete