ReferenceID 695
Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut ( Juglans regia L.) Septum Extract Rich in Bioactive Compounds
Antioxidants (Basel)
The antitussive, antioxidant, and anti-inflammatory effects of a walnut (Juglans regia L.) septum extract (WSE), rich in bioactive compounds were investigated using the citric acid aerosol-induced cough experimental mode
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Record Fields
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- Reference Id
- 695
- Evidence Id
- 17285
- Core Evidence Id
- 17285
- Source Reference Id
- 1373
- Herb2 Reference Id
- HBREF002170
- Subject Paper Key
- HERB001695_33467612
- Pubmed Id
- 33467612
- Doi
- 10.3390/antiox10010119
- Paper Title
- Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut ( Juglans regia L.) Septum Extract Rich in Bioactive Compounds
- Paper Abstract
- The antitussive, antioxidant, and anti-inflammatory effects of a walnut (Juglans regia L.) septum extract (WSE), rich in bioactive compounds were investigated using the citric acid aerosol-induced cough experimental model in rodents. Wistar male rats were treated orally for three days with distilled water (control), codeine (reference), and WSE in graded doses. On the third day, all rats were exposed to citric acid aerosols, the number of coughs being recorded. Each animal was sacrificed after exposure, and blood and lung tissue samples were collected for histopathological analysis and the assessment of oxidative stress and inflammatory biomarkers. The results of the experiment showed a significant antitussive effect of WSE, superior to codeine. This activity could be due to cellular protective effect and anti-inflammatory effect via the stimulation of the antioxidant enzyme system and the decrease of IL-6 and CXC-R1 concentration in the lung tissue of WSE-treated animals. The antioxidant and anti-inflammatory effects of WSE were confirmed by biochemical assays and histopathological analysis. This is the first scientific study reporting the antitussive effect of walnut septum, a new potential source of non-opioid antitussive drug candidates, and a valuable bioactive by-product that could be used in the treatment of respiratory diseases.
- Journal
- Antioxidants (Basel)
- Publish Year
- 2021
- Experiment Subject
- rat; walnut
- Experiment Type
- Animal Experiment
- Phenotype Related
- Respiratory Diseases
- Paper Title Cn
- Paper Title En
- Antitussive, Antioxidant, and Anti-Inflammatory Effects of a Walnut ( Juglans regia L.) Septum Extract Rich in Bioactive Compounds
- Bilingual Status
- semi_complete