ReferenceID 677
The Role of Cashew ( Anacardium occidentale L.) Nuts on an Experimental Model of Painful Degenerative Joint Disease
Antioxidants (Basel)
Osteoarthritis is a progressive joint disease characterized by the activation of different molecular mediators, including proinflammatory cytokines, reactive oxygen species, metalloproteinases and nociceptive mediators.
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Herb: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 677
- Evidence Id
- 17267
- Core Evidence Id
- 17267
- Source Reference Id
- 1344
- Herb2 Reference Id
- HBREF002141
- Subject Paper Key
- HERB001406_32532064
- Pubmed Id
- 32532064
- Doi
- 10.3390/antiox9060511
- Paper Title
- The Role of Cashew ( Anacardium occidentale L.) Nuts on an Experimental Model of Painful Degenerative Joint Disease
- Paper Abstract
- Osteoarthritis is a progressive joint disease characterized by the activation of different molecular mediators, including proinflammatory cytokines, reactive oxygen species, metalloproteinases and nociceptive mediators. Anacardium occidentale L. is a medicinal plant with anti-oxidative and anti-inflammatory properties. In this study we evaluate the effects of cashew nuts (from Anacardium occidentale L.) oral administration on an experimental model of painful degenerative joint disease. Monosodium iodoacetate (MIA) was intraarticularly injected, and cashew nuts were orally administered three times per week for 21 days, starting the third day after MIA injection. Nociception was evaluated by a Von Frey filament test, and motor function by walking track analysis at 3, 7, 14 and 21 days after osteoarthritis. Histological and biochemical alteration were examined at the end of the experiment. Cashew nuts administration reduced pain-like behavior and showed antioxidant activities, restoring biochemical serum parameters: glutathione (GSH), catalase (CAT) levels, glutathione peroxidase (GPx) activity and lipid peroxidation. Moreover, cashew nuts ameliorated radiographic and histological alteration, resulting in decreased cartilage degradation, pro-inflammatory cytokines and metalloproteinases levels and mast cells recruitment. Our results demonstrated that the oral assumption of cashew nuts counteracts the inflammatory and oxidative process involved in osteoarthritis.
- Journal
- Antioxidants (Basel)
- Publish Year
- 2020
- Experiment Subject
- Experiment Type
- Animal Experiment
- Phenotype Related
- Osteoarthritis; Nociception; Painful Degenerative Joint Disease; Joint Disease; Anacardium Occidentale
- Paper Title Cn
- Paper Title En
- The Role of Cashew ( Anacardium occidentale L.) Nuts on an Experimental Model of Painful Degenerative Joint Disease
- Bilingual Status
- semi_complete