ReferenceID 666
Potential roles of dietary flavonoids from Citrus aurantium L. var. amara Engl. in atherosclerosis development
Food Funct
Dietary consumption of flavonoids correlated positively with lower risk of cardiovascular disease. However, the precise roles of flavonoids from the blossoms of Citrus aurantium Linn variant amara Engl (CAVA) in atherosc
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Herb: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 666
- Evidence Id
- 17256
- Core Evidence Id
- 17256
- Source Reference Id
- 1317
- Herb2 Reference Id
- HBREF002114
- Subject Paper Key
- HERB001171_31850465
- Pubmed Id
- 31850465
- Doi
- 10.1039/c9fo02336d
- Paper Title
- Potential roles of dietary flavonoids from Citrus aurantium L. var. amara Engl. in atherosclerosis development
- Paper Abstract
- Dietary consumption of flavonoids correlated positively with lower risk of cardiovascular disease. However, the precise roles of flavonoids from the blossoms of Citrus aurantium Linn variant amara Engl (CAVA) in atherosclerosis (AS) are still poorly understood. This study aimed to find novel flavonoid-type skeletons with protection against AS. Total flavonoids (CAVAF), homoeriodictyol (HE) and hesperetin-7-O-beta-d-glucopyranoside (HG) were isolated from the blossoms of Citrus aurantium Linn variant amara Engl. by chromatography. Their suppressive effects on lipopolysaccharide (LPS)-induced inflammatory responses and ox-LDL-induced foam cell formation were systematically and comparatively investigated using macrophage RAW264.7 cells. HE was more powerful than HG in inhibiting LPS-induced production of nitric oxide (NO), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta) and gene expression in RAW264.7 cells. HE and HG showed different responses to extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinases (JNK), P38, P65, IkappaBalpha, IkappaKalpha/beta phosphorylation, and nuclear factor-kappa B (NF-kappaB) nuclear translocation. HE and HG also differentially decreased oxidized low-density lipoprotein (ox-LDL)-induced foam cell formation by regulating peroxisome proliferator-activated receptor-gamma (PPARgamma), phospholipid ATP-binding cassette transporter A1 (ABCA1), phospholipid ATP-binding cassette transporter G1 (ABCG1), scavenger receptor class B type I (SRB1), scavenger receptor class A type I (SRA1) and cluster of differentiation 36 (CD36) expression at gene and protein levels in RAW264.7 cells. HG showed weaker potential than HE in preventing AS development. Their chemical differences might partially explain the discrepancy in their bioactivity. In conclusion, HE and HG might be developed into novel therapeutic agents against inflammation and AS-associated diseases.
- Journal
- Food Funct
- Publish Year
- 2020
- Experiment Subject
- macrophage raw264.7 cells; raw264.7 cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Atherosclerosis; Cardiovascular Disease; Inflammation
- Paper Title Cn
- Paper Title En
- Potential roles of dietary flavonoids from Citrus aurantium L. var. amara Engl. in atherosclerosis development
- Bilingual Status
- semi_complete