ReferenceID 6510
Wogonin regulates colonocyte metabolism via PPARγ to inhibit Enterobacteriaceae against dextran sulfate sodium-induced colitis in mice
Phytother Res
To investigate the potential effects and mechanism of wogonin on dextran sulfate sodium (DSS)-induced colitis, 70 male mice were administered wogonin (12.5, 25, 50 mg·kg -1 ·d -1 , i.g.) for 10 days, meanwhile, in order
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Record Fields
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- Reference Id
- 6510
- Evidence Id
- 23100
- Core Evidence Id
- 23100
- Source Reference Id
- 6316
- Herb2 Reference Id
- HBREF007113
- Subject Paper Key
- HBIN048372_36451541
- Pubmed Id
- 36451541
- Doi
- 10.1002/ptr.7677
- Paper Title
- Wogonin regulates colonocyte metabolism via PPARγ to inhibit Enterobacteriaceae against dextran sulfate sodium-induced colitis in mice
- Paper Abstract
- To investigate the potential effects and mechanism of wogonin on dextran sulfate sodium (DSS)-induced colitis, 70 male mice were administered wogonin (12.5, 25, 50 mg·kg -1 ·d -1 , i.g.) for 10 days, meanwhile, in order to induce colitis, the mice were free to drink 3% DSS for 6 days. We found that wogonin could obviously ameliorate DSS-induced colitis, including preventing colon shortening and inhibiting pathological damage. In addition, wogonin could increase the expression of PPARγ, which not only restores intestinal epithelial hypoxia but also inhibits iNOS protein to reduce intestinal nitrite levels. All these effects facilitated a reduction in the abundance of Enterobacteriaceae in DSS-induced colitis mice. Therefore, compared with the DSS group, the number of Enterobacteriaceae in the intestinal flora was significantly reduced after administration of wogonin or rosiglitazone by 16s rDNA technology. We also verified that wogonin could promote the expression of PPARγ mRNA and protein in Caco-2 cells, and this effect disappeared when PPARγ signal was inhibited. In conclusion, our study suggested that wogonin can activate the PPARγ signal of the Intestinal epithelium to ameliorate the Intestinal inflammation caused by Enterobacteriaceae bacteria expansion.
- Journal
- Phytother Res
- Publish Year
- 2022
- Experiment Subject
- mouse; caco-2 cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Colitis; Colon Shortening; Intestinal Inflammation
- Paper Title Cn
- Paper Title En
- Wogonin regulates colonocyte metabolism via PPARγ to inhibit Enterobacteriaceae against dextran sulfate sodium-induced colitis in mice
- Bilingual Status
- semi_complete