ReferenceID 6508
Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4-FGF21 Signaling in Mouse Hepatocyte AML12 Cells
Nutrients
Fibroblast growth factor 21 (FGF21), which is mainly synthesized and secreted by the liver, plays a crucial role in systemic glucose and lipid metabolism, ameliorating metabolic diseases. In this study, we screened the W
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 6508
- Evidence Id
- 23098
- Core Evidence Id
- 23098
- Source Reference Id
- 6314
- Herb2 Reference Id
- HBREF007111
- Subject Paper Key
- HBIN048372_36235573
- Pubmed Id
- 36235573
- Doi
- 10.3390/nu14193920
- Paper Title
- Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4-FGF21 Signaling in Mouse Hepatocyte AML12 Cells
- Paper Abstract
- Fibroblast growth factor 21 (FGF21), which is mainly synthesized and secreted by the liver, plays a crucial role in systemic glucose and lipid metabolism, ameliorating metabolic diseases. In this study, we screened the WAKANYAKU library derived from medicinal herbs to identify compounds that can activate Fgf21 expression in mouse hepatocyte AML12 cells. We identified Scutellaria baicalensis root extract and one of its components, wogonin, as an activator of Fgf21 expression. Wogonin also enhanced the expression of activating transcription factor 4 (ATF4) by a mechanism other than ER stress. Knockdown of ATF4 by siRNA suppressed wogonin-induced Fgf21 expression, highlighting its essential role in wogonin's mode of action. Thus, our results indicate that wogonin would be a strong candidate for a therapeutic to improve metabolic diseases by enhancing hepatic FGF21 production.
- Journal
- Nutrients
- Publish Year
- 2022
- Experiment Subject
- mouse; mouse hepatocyte aml12 cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Metabolic Diseases
- Paper Title Cn
- Paper Title En
- Wogonin, a Compound in Scutellaria baicalensis, Activates ATF4-FGF21 Signaling in Mouse Hepatocyte AML12 Cells
- Bilingual Status
- semi_complete