ReferenceID 6502
Wogonin ameliorate complete Freund's adjuvant induced rheumatoid arthritis via targeting NF-κB/MAPK signaling pathway
Biofactors
Rheumatoid arthritis (RA) is a chronic and accelerated autoimmune illness with proliferative and damaging synovitis, resulting in joint death and cartilage and bone erosion. This study focused on the potential therapeuti
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 6502
- Evidence Id
- 23092
- Core Evidence Id
- 23092
- Source Reference Id
- 6301
- Herb2 Reference Id
- HBREF007098
- Subject Paper Key
- HBIN048372_31721330
- Pubmed Id
- 31721330
- Doi
- 10.1002/biof.1585
- Paper Title
- Wogonin ameliorate complete Freund's adjuvant induced rheumatoid arthritis via targeting NF-κB/MAPK signaling pathway
- Paper Abstract
- Rheumatoid arthritis (RA) is a chronic and accelerated autoimmune illness with proliferative and damaging synovitis, resulting in joint death and cartilage and bone erosion. This study focused on the potential therapeutic effect of wogonin on complete Freund's adjuvant (CFA) induced RA in rats and the underlying mechanisms. Arthritis was experimentally caused in rats by subcutaneously injecting 0.1 mL of CFA into the subplantar area of the left hind paw under moderate anesthesia on day zero. The regular oral doses of indomethacin/wogonin began on day zero and proceeded after injection to day 35. Wogonin reduced arthritic score considerably, enhanced body weight, and reduced paw thickness. Wogonin also boosted red blood cell considerably along with hemoglobin and reduced white blood cell count and erythrocyte sedimentation rate. Wogonin substantially improved an altered level of oxidative stress markers, antioxidant proteins, and inflammatory cytokines in a dose-dependent way. Wogonin inhibited p38 phosphorylation triggered by CFA and p65 nuclear translocation.
- Journal
- Biofactors
- Publish Year
- 2020
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Cartilage And Bone Erosion; Synovitis; Chronic And Accelerated Autoimmune Illness; Rheumatoid Arthritis; Arthritis; Joint Death; Complete Freund's Adjuvant
- Paper Title Cn
- Paper Title En
- Wogonin ameliorate complete Freund's adjuvant induced rheumatoid arthritis via targeting NF-κB/MAPK signaling pathway
- Bilingual Status
- semi_complete