ReferenceID 6479
Pantothenate protects against obesity via brown adipose tissue activation
Am J Physiol Endocrinol Metab
Brown adipose tissue (BAT) is the primary site of adaptive thermogenesis, which is involved in energy expenditure and has received much attention in the field of obesity treatment. By screening a small-molecule compound
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 6479
- Evidence Id
- 23069
- Core Evidence Id
- 23069
- Source Reference Id
- 6250
- Herb2 Reference Id
- HBREF007047
- Subject Paper Key
- HBIN048044_35575231
- Pubmed Id
- 35575231
- Doi
- 10.1152/ajpendo.00293.2021
- Paper Title
- Pantothenate protects against obesity via brown adipose tissue activation
- Paper Abstract
- Brown adipose tissue (BAT) is the primary site of adaptive thermogenesis, which is involved in energy expenditure and has received much attention in the field of obesity treatment. By screening a small-molecule compound library of drugs approved by the Food and Drug Administration, pantothenic acid was identified as being able to significantly upregulate the expression of uncoupling protein 1 (UCP1), a key thermogenic protein found in BAT. Pantothenate (PA) treatment decreased adiposity, reversed hepatic steatosis, and improved glucose homeostasis by increasing energy expenditure in C57BL/6J mice fed a high-fat diet. PA also significantly increased BAT activity and induced beige adipocytes formation. Mechanistically, the beneficial effects were mediated by UCP1 because PA treatment was unable to ameliorate obesity in UCP1 knockout mice. In conclusion, we identified PA as an effective BAT activator that can prevent obesity and may represent a promising strategy for the clinical treatment of obesity and related metabolic diseases. NEW & NOTEWORTHY PA treatment effectively and safely protected against obesity via the BAT-UCP1 axis. PA has therapeutic potential for treating obesity and type II diabetes.
- Journal
- Am J Physiol Endocrinol Metab
- Publish Year
- 2022
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Obesity; Type Ii Diabetes; Metabolic Diseases
- Paper Title Cn
- Paper Title En
- Pantothenate protects against obesity via brown adipose tissue activation
- Bilingual Status
- semi_complete