ReferenceID 6468
Sophoraflavanone G from Sophora flavescens Ameliorates Allergic Airway Inflammation by Suppressing Th2 Response and Oxidative Stress in a Murine Asthma Model
Int J Mol Sci
Sophoraflavanone G (SG), isolated from Sophora flavescens , has anti-inflammatory and anti-tumor bioactive properties. We previously showed that SG promotes apoptosis in human breast cancer cells and leukemia cells and r
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Record Fields
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- Reference Id
- 6468
- Evidence Id
- 23058
- Core Evidence Id
- 23058
- Source Reference Id
- 6233
- Herb2 Reference Id
- HBREF007030
- Subject Paper Key
- HBIN047880_35682783
- Pubmed Id
- 35682783
- Doi
- 10.3390/ijms23116104
- Paper Title
- Sophoraflavanone G from Sophora flavescens Ameliorates Allergic Airway Inflammation by Suppressing Th2 Response and Oxidative Stress in a Murine Asthma Model
- Paper Abstract
- Sophoraflavanone G (SG), isolated from Sophora flavescens , has anti-inflammatory and anti-tumor bioactive properties. We previously showed that SG promotes apoptosis in human breast cancer cells and leukemia cells and reduces the inflammatory response in lipopolysaccharide-stimulated macrophages. We investigated whether SG attenuates airway hyper-responsiveness (AHR) and airway inflammation in asthmatic mice. We also assessed its effects on the anti-inflammatory response in human tracheal epithelial cells. Female BALB/c mice were sensitized with ovalbumin, and asthmatic mice were treated with SG by intraperitoneal injection. We also exposed human bronchial epithelial BEAS-2B cells to different concentrations of SG to evaluate its effects on inflammatory cytokine levels. SG treatment significantly reduced AHR, eosinophil infiltration, goblet cell hyperplasia, and airway inflammation in the lungs of asthmatic mice. In the lungs of ovalbumin-sensitized mice, SG significantly promoted superoxide dismutase and glutathione expression and attenuated malondialdehyde levels. SG also suppressed levels of Th2 cytokines and chemokines in lung and bronchoalveolar lavage samples. In addition, we confirmed that SG decreased pro-inflammatory cytokine, chemokine, and eotaxin expression in inflammatory BEAS-2B cells. Taken together, our data demonstrate that SG shows potential as an immunomodulator that can improve asthma symptoms by decreasing airway-inflammation-related oxidative stress.
- Journal
- Int J Mol Sci
- Publish Year
- 2022
- Experiment Subject
- mouse; human; human bronchial epithelial beas-2b cells; inflammatory beas-2b cells; lipopolysaccharide-stimulated macrophages
- Experiment Type
- Animal Experiment
- Phenotype Related
- Airway Inflammation; Goblet Cell Hyperplasia; Airway Hyper-responsiveness; Leukemia; Asthma; Asthmatic; Breast Cancer
- Paper Title Cn
- Paper Title En
- Sophoraflavanone G from Sophora flavescens Ameliorates Allergic Airway Inflammation by Suppressing Th2 Response and Oxidative Stress in a Murine Asthma Model
- Bilingual Status
- semi_complete