ReferenceID 6464
Maltol prevents the progression of osteoarthritis by targeting PI3K/Akt/NF-κB pathway: In vitro and in vivo studies
J Cell Mol Med
Osteoarthritis (OA), a prevalent degenerative arthritis disease, principle characterized by the destruction of cartilage and associated with the inflammatory response. Maltol, a product formed during the processing of re
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Record Fields
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- Reference Id
- 6464
- Evidence Id
- 23054
- Core Evidence Id
- 23054
- Source Reference Id
- 6226
- Herb2 Reference Id
- HBREF007023
- Subject Paper Key
- HBIN047879_33211383
- Pubmed Id
- 33211383
- Doi
- 10.1111/jcmm.16104
- Paper Title
- Maltol prevents the progression of osteoarthritis by targeting PI3K/Akt/NF-κB pathway: In vitro and in vivo studies
- Paper Abstract
- Osteoarthritis (OA), a prevalent degenerative arthritis disease, principle characterized by the destruction of cartilage and associated with the inflammatory response. Maltol, a product formed during the processing of red ginseng (Panax ginseng, CA Meyer), has been reported to have the potential effect of anti-inflammatory. However, its specific mechanisms are not demonstrated. We investigated the protective effect of maltol in the progression of OA both in vitro and in vivo experiments. Human chondrocytes were pre-treated with maltol (0, 20, 40, 60 muM, 24 hours) and incubated with IL-1beta (10 ng/mL, 24 hours) in vitro. Expression of PGE2, TNF-alpha and NO was measured by the ELISA and Griess reaction. The expression of iNOs, COX-2, aggrecan, ADAMTS-5, MMP-13, IkappaB-alpha, p65, P-AKT, AKT, PI3K and P-PI3K was analysed by Western blotting. The expression of collagen II and p65-active protein was detected by immunofluorescence. Moreover, the serious level of OA was evaluated by histological analysis in vivo. We identified that maltol could suppress the IL-1beta-stimulated generation of PGE2 and NO. Besides, maltol not only suppressed the production of COX-2, iNOs, TNF-alpha, IL-6, ADAMTS-5, MMP-13, but also attenuated the degradation of collagen II and aggrecan. Furthermore, maltol remarkably suppressed the phosphorylation of PI3K/AKT and NF-kappaB induced by IL-1beta in human OA chondrocytes. Moreover, maltol could block the cartilage destroy in OA mice in vivo. To date, all data indicate maltol is a potential therapeutic agent by inhibiting inflammatory response via the regulation of NF-kappaB signalling for OA.
- Journal
- J Cell Mol Med
- Publish Year
- 2021
- Experiment Subject
- mouse; human; ginseng
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Degenerative Arthritis Disease; Osteoarthritis
- Paper Title Cn
- Paper Title En
- Maltol prevents the progression of osteoarthritis by targeting PI3K/Akt/NF-κB pathway: In vitro and in vivo studies
- Bilingual Status
- semi_complete