ReferenceID 6459
Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced Drosophila Ulcerative Colitis Model by Inhibiting the JNK Signaling
Antioxidants (Basel)
Ursolic acid (UA) is a bioactive molecule widely distributed in various fruits and vegetables, which was reported to play a therapeutic role in ulcerative colitis (UC) induced by toxic chemicals. However, the underlying
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Record Fields
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- Reference Id
- 6459
- Evidence Id
- 23049
- Core Evidence Id
- 23049
- Source Reference Id
- 6208
- Herb2 Reference Id
- HBREF007005
- Subject Paper Key
- HBIN047613_35204308
- Pubmed Id
- 35204308
- Doi
- 10.3390/antiox11020426
- Paper Title
- Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced Drosophila Ulcerative Colitis Model by Inhibiting the JNK Signaling
- Paper Abstract
- Ursolic acid (UA) is a bioactive molecule widely distributed in various fruits and vegetables, which was reported to play a therapeutic role in ulcerative colitis (UC) induced by toxic chemicals. However, the underlying mechanism has not been well clarified in vivo. Here, using a Drosophila UC model induced by sodium dodecyl sulfate (SDS), we investigated the defensive effect of UA on intestinal damage. The results showed that UA could significantly protect Drosophila from the damage caused by SDS exposure. Further, UA alleviated the accumulation of reactive oxygen species (ROS) and malondialdehyde (MDA) induced by SDS and upregulated the activities of total superoxide dismutase (T-SOD) and catalase (CAT). Moreover, the proliferation and differentiation of intestine stem cells (ISCs) as well as the excessive activation of the c-Jun N-terminal kinase (JNK)-dependent JAK/STAT signaling pathway induced by SDS were restored by UA. In conclusion, UA prevents intestine injury from toxic compounds by reducing the JNK/JAK/STAT signaling pathway. UA may provide a theoretical basis for functional food or natural medicine development.
- Journal
- Antioxidants (Basel)
- Publish Year
- 2022
- Experiment Subject
- drosophila
- Experiment Type
- Animal Experiment
- Phenotype Related
- Ulcerative Colitis
- Paper Title Cn
- Paper Title En
- Ursolic Acid Protects Sodium Dodecyl Sulfate-Induced Drosophila Ulcerative Colitis Model by Inhibiting the JNK Signaling
- Bilingual Status
- semi_complete