ReferenceID 6363
Caffeic Acid Modulates Processes Associated with Intestinal Inflammation
Nutrients
Caffeic acid is one of the most abundant hydroxycinnamic acids in fruits, vegetables, and beverages. This phenolic compound reaches relevant concentrations in the colon (up to 126 microM) where it could come into contact
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 6363
- Evidence Id
- 22953
- Core Evidence Id
- 22953
- Source Reference Id
- 5998
- Herb2 Reference Id
- HBREF006795
- Subject Paper Key
- HBIN046726_33567596
- Pubmed Id
- 33567596
- Doi
- 10.3390/nu13020554
- Paper Title
- Caffeic Acid Modulates Processes Associated with Intestinal Inflammation
- Paper Abstract
- Caffeic acid is one of the most abundant hydroxycinnamic acids in fruits, vegetables, and beverages. This phenolic compound reaches relevant concentrations in the colon (up to 126 microM) where it could come into contact with the intestinal cells and exert its anti-inflammatory effects. The aim of this investigation was to study the capacity of caffeic acid, at plausible concentrations from an in vivo point of view, to modulate mechanisms related to intestinal inflammation. Consequently, we tested the effects of caffeic acid (50-10 microM) on cyclooxygenase (COX)-2 expression and prostaglandin (PG)E2, cytokines, and chemokines (IL-8, monocyte chemoattractant protein-1 -MCP-1-, and IL-6) biosynthesis in IL-1beta-treated human myofibroblasts of the colon, CCD-18Co. Furthermore, the capacity of caffeic acid to inhibit the angiotensin-converting enzyme (ACE) activity, to hinder advanced glycation end product (AGE) formation, as well as its antioxidant, reducing, and chelating activity were also investigated. Our results showed that (i) caffeic acid targets COX-2 and its product PGE2 as well as the biosynthesis of IL-8 in the IL-1beta-treated cells and (ii) inhibits AGE formation, which could be related to (iii) the high chelating activity exerted. Low anti-ACE, antioxidant, and reducing capacity of caffeic acid was also observed. These effects of caffeic acid expands our knowledge on anti-inflammatory mechanisms against intestinal inflammation.
- Journal
- Nutrients
- Publish Year
- 2021
- Experiment Subject
- human; il-1beta-treated cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Intestinal Inflammation
- Paper Title Cn
- Paper Title En
- Caffeic Acid Modulates Processes Associated with Intestinal Inflammation
- Bilingual Status
- semi_complete