ReferenceID 6358
Innate Immune Response against Staphylococcus aureus Preincubated with Subinhibitory Concentration of trans-Anethole
Int J Mol Sci
The study aimed to analyze morphological and functional changes of Staphylococcus aureus cells due to trans-anethole (a terpenoid and the major constituent of fennel, anise, or star anise essential oils) exposition, and
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Record Fields
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- Reference Id
- 6358
- Evidence Id
- 22948
- Core Evidence Id
- 22948
- Source Reference Id
- 5990
- Herb2 Reference Id
- HBREF006787
- Subject Paper Key
- HBIN046713_32545315
- Pubmed Id
- 32545315
- Doi
- 10.3390/ijms21114178
- Paper Title
- Innate Immune Response against Staphylococcus aureus Preincubated with Subinhibitory Concentration of trans-Anethole
- Paper Abstract
- The study aimed to analyze morphological and functional changes of Staphylococcus aureus cells due to trans-anethole (a terpenoid and the major constituent of fennel, anise, or star anise essential oils) exposition, and their consequences for human neutrophils phagocytic activity as well as IL-8 production (recognized as the major chemoattractant). The investigation included the evaluation of changes occurring in S. aureus cultures, i.e., staphyloxanthin production, antioxidant activities, cell size distribution, and cells composition as a result of incubation with trans-anethole. It was found that the presence of trans-anethole in the culture medium reduced the level of staphyloxanthin production, as well as decreased antioxidant activities. Furthermore, trans-anethole-treated cells were characterized by larger size and a tendency to diffuse in comparison to the non-treated cells. Several cell components, such as phospholipids and peptidoglycan, were found remarkably elevated in the cultures treated with trans-anethole. As a result of the aforementioned cellular changes, the bacteria were phagocytized by neutrophils more efficiently (ingestion and parameters associated with killing activity were at a higher level as compared to the control system). Additionally, IL-8 production was at a higher level for trans-anethole modified bacteria. Our results suggest that trans-anethole represents a promising measure in combating severe staphylococcal infections, which has an important translational potential for clinical applications.
- Journal
- Int J Mol Sci
- Publish Year
- 2020
- Experiment Subject
- human; non-treated cells; trans-anethole-treated cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Staphylococcal Infections
- Paper Title Cn
- Paper Title En
- Innate Immune Response against Staphylococcus aureus Preincubated with Subinhibitory Concentration of trans-Anethole
- Bilingual Status
- semi_complete