ReferenceID 6349
Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity
Cell Mol Immunol
Neutrophils are derived from bone marrow hematopoietic stem cells (HSCs) and are the largest population among circulating white blood cells in humans, acting as the first line of defense against invading pathogens. Wheth
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 6349
- Evidence Id
- 22939
- Core Evidence Id
- 22939
- Source Reference Id
- 5973
- Herb2 Reference Id
- HBREF006770
- Subject Paper Key
- HBIN046383_35301470
- Pubmed Id
- 35301470
- Doi
- 10.1038/s41423-022-00842-9
- Paper Title
- Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity
- Paper Abstract
- Neutrophils are derived from bone marrow hematopoietic stem cells (HSCs) and are the largest population among circulating white blood cells in humans, acting as the first line of defense against invading pathogens. Whether neutrophils can be generated by transdifferentiation strategies is unknown. Here, we show that thymidine induces the conversion of mouse fibroblasts to neutrophils. Induced neutrophils (iNeus) showed antibacterial effects and did not undergo malignant transformation in vivo. Importantly, iNeu transplantation cured neutropenia in mice in vivo. Mechanistically, thymidine mediates iNeu conversion by enhancing Tet3 activity. Tet3 initiates the expression of the neutrophil fate decision factors Cebpδ and Rfx1 that drive the transdifferentiation of mouse fibroblasts to neutrophils. Therefore, the induction of functional neutrophils by chemicals may provide a potential therapeutic strategy for patients with neutropenia patients and infectious diseases.Fibroblasts; Neutrophils; Thymidine; Transdifferentiation; Tet3.
- Journal
- Cell Mol Immunol
- Publish Year
- 2022
- Experiment Subject
- mouse; human; patient
- Experiment Type
- Animal Experiment
- Phenotype Related
- Infectious Diseases; Neutropenia
- Paper Title Cn
- Paper Title En
- Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity
- Bilingual Status
- semi_complete