ReferenceID 6308
Taxifolin ameliorate high-fat-diet feeding plus acute ethanol binge-induced steatohepatitis through inhibiting inflammatory caspase-1-dependent pyroptosis
Food Funct
Excessive alcohol drinking and a high-fat diet (HFD) promote steatohepatitis in the comorbidity of NAFLD and AFLD. Taxifolin (TAX) is a rich dihydroxyflavone compound found in onions, milk thistle and Douglas fir. We aim
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Record Fields
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- Reference Id
- 6308
- Evidence Id
- 22898
- Core Evidence Id
- 22898
- Source Reference Id
- 5887
- Herb2 Reference Id
- HBREF006684
- Subject Paper Key
- HBIN045672_33325949
- Pubmed Id
- 33325949
- Doi
- 10.1039/d0fo02653k
- Paper Title
- Taxifolin ameliorate high-fat-diet feeding plus acute ethanol binge-induced steatohepatitis through inhibiting inflammatory caspase-1-dependent pyroptosis
- Paper Abstract
- Excessive alcohol drinking and a high-fat diet (HFD) promote steatohepatitis in the comorbidity of NAFLD and AFLD. Taxifolin (TAX) is a rich dihydroxyflavone compound found in onions, milk thistle and Douglas fir. We aimed to explore the intervention mechanism of TAX on chronic steatohepatitis induced by HFD feeding plus acute ethanol binge. We established an in vivo model by HFD feeding plus a single dose of ethanol binge, and established an in vitro model by oleic acid or palmitic acid on HepG2 cells to induce lipid accumulation. TAX regulated lipid synthesis by inhibiting the expression of SREBP1 and upregulating the PPARgamma level. In addition, TAX inhibited the expression of P2X7R, IL-1beta, and caspase-1. Moreover, TAX reduced the expression of caspase-1 activation; thereby inhibiting the recruitment of macrophages and neutrophils. TAX also improved the inflammatory response caused by caspase-1 activation in steatotic hepatocytes. TAX exhibited an inhibitory effect on lipid accumulation and caspase-1-related pyroptosis. Collectively, TAX has therapeutic potential as an intervention of steatohepatitis induced by alcohol combined with HFD and for preventing non-alcoholic fatty liver degeneration targeting caspase-1-dependent pyroptosis.
- Journal
- Food Funct
- Publish Year
- 2021
- Experiment Subject
- hepg2 cells; milk; onion
- Experiment Type
- Cell Experiment
- Phenotype Related
- Chronic Steatohepatitis; Non-alcoholic Fatty Liver Degeneration; Steatohepatitis; Caspase-1-dependent Pyroptosis
- Paper Title Cn
- Paper Title En
- Taxifolin ameliorate high-fat-diet feeding plus acute ethanol binge-induced steatohepatitis through inhibiting inflammatory caspase-1-dependent pyroptosis
- Bilingual Status
- semi_complete