ReferenceID 6266
Induction of the Nrf2 Pathway by Sulforaphane Is Neuroprotective in a Rat Temporal Lobe Epilepsy Model
Antioxidants (Basel)
Epilepsy is a chronic disease of the brain that affects over 65 million people worldwide. Acquired epilepsy is initiated by neurological insults, such as status epilepticus, which can result in the generation of ROS and
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- Reference Id
- 6266
- Evidence Id
- 22856
- Core Evidence Id
- 22856
- Source Reference Id
- 5811
- Herb2 Reference Id
- HBREF006608
- Subject Paper Key
- HBIN045135_34829573
- Pubmed Id
- 34829573
- Doi
- 10.3390/antiox10111702
- Paper Title
- Induction of the Nrf2 Pathway by Sulforaphane Is Neuroprotective in a Rat Temporal Lobe Epilepsy Model
- Paper Abstract
- Epilepsy is a chronic disease of the brain that affects over 65 million people worldwide. Acquired epilepsy is initiated by neurological insults, such as status epilepticus, which can result in the generation of ROS and induction of oxidative stress. Suppressing oxidative stress by upregulation of the transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2) has been shown to be an effective strategy to increase endogenous antioxidant defences, including in brain diseases, and can ameliorate neuronal damage and seizure occurrence in epilepsy. Here, we aim to test the neuroprotective potential of a naturally occurring Nrf2 activator sulforaphane, in in vitro epileptiform activity model and a temporal lobe epilepsy rat model. Sulforaphane significantly decreased ROS generation during epileptiform activity, restored glutathione levels, and prevented seizure-like activity-induced neuronal cell death. When given to rats after 2 h of kainic acid-induced status epilepticus, sulforaphane significantly increased the expression of Nrf2 and related antioxidant genes, improved oxidative stress markers, and increased the total antioxidant capacity in both the plasma and hippocampus. In addition, sulforaphane significantly decreased status epilepticus-induced neuronal cell death. Our results demonstrate that Nrf2 activation following an insult to the brain exerts a neuroprotective effect by reducing neuronal death, increasing the antioxidant capacity, and thus may also modify epilepsy development.
- Journal
- Antioxidants (Basel)
- Publish Year
- 2021
- Experiment Subject
- rat; people
- Experiment Type
- Animal Experiment
- Phenotype Related
- Brain Diseases; Neurological Insults; Status Epilepticus; Epilepsy; Temporal Lobe Epilepsy; Acquired Epilepsy; Chronic Disease Of The Brain
- Paper Title Cn
- Paper Title En
- Induction of the Nrf2 Pathway by Sulforaphane Is Neuroprotective in a Rat Temporal Lobe Epilepsy Model
- Bilingual Status
- semi_complete