ReferenceID 6241
Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies
Food Funct
Intervertebral disc degeneration (IDD) has been reported to be a major cause of low back pain. Stachydrine (STA) is present in the fruit juice of the Citrus genus and Leonurus heterophyllus, in non-negligible concentrati
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 6241
- Evidence Id
- 22831
- Core Evidence Id
- 22831
- Source Reference Id
- 5760
- Herb2 Reference Id
- HBREF006557
- Subject Paper Key
- HBIN044690_33245081
- Pubmed Id
- 33245081
- Doi
- 10.1039/d0fo02323j
- Paper Title
- Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies
- Paper Abstract
- Intervertebral disc degeneration (IDD) has been reported to be a major cause of low back pain. Stachydrine (STA) is present in the fruit juice of the Citrus genus and Leonurus heterophyllus, in non-negligible concentrations. In our study, we examined the protective effects of STA against IDD development as well as its underlying mechanism of action using both in vitro and in vivo experiments. STA exerted protective effects on the anabolism and catabolism of the extracellular matrix (ECM) in IL-1beta-treated NPCs and inhibited the expression of pro-inflammatory factors in vitro. Mechanistically, STA suppressed the IL-1beta-induced activation of PI3K/Akt/NF-kappaB signalling pathway cascades. Moreover, it was also demonstrated in molecular docking studies that STA has strong binding abilities to PI3K. Furthermore, STA ameliorated the progression of the IDD process in vivo in the puncture-induced rat model. In summary, our findings demonstrated that STA ameliorates the progression of IDD via the PI3K/Akt/NF-kappaB signalling pathway, which makes STA a promising therapeutic agent for the treatment of IDD.
- Journal
- Food Funct
- Publish Year
- 2020
- Experiment Subject
- rat; il-1beta-treated npcs
- Experiment Type
- Cell Experiment
- Phenotype Related
- Intervertebral Disc Degeneration; Low Back Pain
- Paper Title Cn
- Paper Title En
- Stachydrine ameliorates the progression of intervertebral disc degeneration via the PI3K/Akt/NF-κB signaling pathway: in vitro and in vivo studies
- Bilingual Status
- semi_complete