ReferenceID 624
Modulation of the Aβ-Peptide-Aggregation Pathway by Active Compounds From Platycladus orientalis Seed Extract in Alzheimer's Disease Models
Front Aging Neurosci
Alzheimer's disease (AD) is a neurodegenerative disease characterized by neuronal loss, cognitive impairment, and aphasia. Aggregation of beta-amyloid (Abeta) peptide in the brain is considered a key mechanism in the dev
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- Reference Id
- 624
- Evidence Id
- 17214
- Core Evidence Id
- 17214
- Source Reference Id
- 1240
- Herb2 Reference Id
- HBREF002037
- Subject Paper Key
- HERB000615_32922281
- Pubmed Id
- 32922281
- Doi
- 10.3389/fnagi.2020.00207
- Paper Title
- Modulation of the Aβ-Peptide-Aggregation Pathway by Active Compounds From Platycladus orientalis Seed Extract in Alzheimer's Disease Models
- Paper Abstract
- Alzheimer's disease (AD) is a neurodegenerative disease characterized by neuronal loss, cognitive impairment, and aphasia. Aggregation of beta-amyloid (Abeta) peptide in the brain is considered a key mechanism in the development of AD. In the past 20 years, many compounds have been developed to inhibit Abeta aggregation and accelerate its degradation. Platycladus orientalis seed is a traditional Chinese medicine used to enhance intelligence and slow aging. We previously found that Platycladus orientalis seed extract (EPOS) inhibited Abeta-peptide aggregation in the hippocampus and reduced cognitive deficits in 5xFAD mice. However, the mechanisms of these effects have not been characterized. To characterize the protective mechanisms of EPOS, we used a transgenic Caenorhabditis elegans CL4176 model to perform Bioactivity-guided identification of active compounds. Four active compounds, comprising communic acid, isocupressic acid, imbricatolic acid, and pinusolide, were identified using 13C-and 1H-NMR spectroscopy. Furthermore, we showed that isocupressic acid inhibited Abeta generation by modulating BACE1 activity via the GSK3beta/NF-kappaB pathway in HEK293-APPsw cells. These findings showed that EPOS reduced cognitive deficits in an AD model via modulation of the Abeta peptide aggregation pathway.
- Journal
- Front Aging Neurosci
- Publish Year
- 2020
- Experiment Subject
- mouse; hek293-appsw cells
- Experiment Type
- Animal Experiment
- Phenotype Related
- Alzheimer's Disease; Cognitive Impairment; Neuronal Loss; Aphasia; Neurodegenerative Disease; Cognitive Deficits; 5xfad
- Paper Title Cn
- Paper Title En
- Modulation of the Aβ-Peptide-Aggregation Pathway by Active Compounds From Platycladus orientalis Seed Extract in Alzheimer's Disease Models
- Bilingual Status
- semi_complete