ReferenceID 6226
Solamargine Alleviated UVB-Induced Inflammation and Melanogenesis in Human Keratinocytes and Melanocytes via the p38 MAPK Signaling Pathway, a Promising Agent for Post-inflammatory Hyperpigmentation
Front Med (Lausanne)
Post-inflammatory hyperpigmentation (PIH) is a common acquired pigmentary disorder occurring after skin inflammation or injury. Ultraviolet B irradiation could exaggerate PIH clinically due to its effect on promoting cut
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Record Fields
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- Reference Id
- 6226
- Evidence Id
- 22816
- Core Evidence Id
- 22816
- Source Reference Id
- 5732
- Herb2 Reference Id
- HBREF006529
- Subject Paper Key
- HBIN044265_35770009
- Pubmed Id
- 35770009
- Doi
- 10.3389/fmed.2022.812653
- Paper Title
- Solamargine Alleviated UVB-Induced Inflammation and Melanogenesis in Human Keratinocytes and Melanocytes via the p38 MAPK Signaling Pathway, a Promising Agent for Post-inflammatory Hyperpigmentation
- Paper Abstract
- Post-inflammatory hyperpigmentation (PIH) is a common acquired pigmentary disorder occurring after skin inflammation or injury. Ultraviolet B irradiation could exaggerate PIH clinically due to its effect on promoting cutaneous inflammation and melanogenesis in keratinocytes and melanocytes, respectively. Solamargine (SM), a steroidal alkaloid glycoside extracted from Solanum undatum , significantly inhibits Ultraviolet B (UVB)-induced pro-inflammatory cytokines IL-1α, IL-1β, IL-8, and IFN-γ, as well as paracrine melanogenic factors ET-1, α-MSH, and bFGF in human keratinocytes. Additionally, SM significantly attenuated UVB-induced melanin synthesis in human epidermal melanocytes through down-regulation of tyrosinase activity and expression of MITF, TRP-1, TRP-2, and tyrosinase. SM exerted an anti-inflammatory effect in UVB-irradiated keratinocytes through the p38 MAPK/Nrf2/HO-1 signaling pathway. With its anti-inflammatory and whitening effect, SM may improve PIH through paracrine regulations of keratinocytes and direct action on melanocytes, making it a promising agent for PIH.
- Journal
- Front Med (Lausanne)
- Publish Year
- 2022
- Experiment Subject
- human; uvb-irradiated keratinocytes
- Experiment Type
- Cell Experiment
- Phenotype Related
- Cutaneous Inflammation; Post-inflammatory Hyperpigmentation; Skin Inflammation; Acquired Pigmentary Disorder
- Paper Title Cn
- Paper Title En
- Solamargine Alleviated UVB-Induced Inflammation and Melanogenesis in Human Keratinocytes and Melanocytes via the p38 MAPK Signaling Pathway, a Promising Agent for Post-inflammatory Hyperpigmentation
- Bilingual Status
- semi_complete