ReferenceID 6218
Sinigrin Enhanced Antiasthmatic Effects of Beta Adrenergic Receptors Agonists by Regulating cAMP-Mediated Pathways
Front Pharmacol
Millions of patients suffer from asthma worldwide. However, the first-line drugs used to treat asthma, namely, the beta-adrenergic receptors agonists (beta-agonists), are not recommended for use as monotherapy because of
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Record Fields
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- Reference Id
- 6218
- Evidence Id
- 22808
- Core Evidence Id
- 22808
- Source Reference Id
- 5716
- Herb2 Reference Id
- HBREF006513
- Subject Paper Key
- HBIN044087_32508648
- Pubmed Id
- 32508648
- Doi
- 10.3389/fphar.2020.00723
- Paper Title
- Sinigrin Enhanced Antiasthmatic Effects of Beta Adrenergic Receptors Agonists by Regulating cAMP-Mediated Pathways
- Paper Abstract
- Millions of patients suffer from asthma worldwide. However, the first-line drugs used to treat asthma, namely, the beta-adrenergic receptors agonists (beta-agonists), are not recommended for use as monotherapy because of their severe dose-related side effects. This limitation has prompted the search for new therapies, which can be used in conjunction with beta--agonists so that lower doses can be administered. Sinigrin is a major compound found in many antiasthmatic medicinal plants. In this study, we explored the antiasthmatic activity of sinigrin when used in combination with beta-agonists and its underlying mechanism. Sinigrin enhanced the asthma-relieving effects of isoproterenol and reduced the effective isoproterenol dose in an acute-asthma model in guinea pigs. Mechanistically, sinigrin enhanced the cAMP levels induced by beta-agonists by inhibiting PDE4. The resulting increase in cAMP levels stimulated the activity of the downstream effector protein kinase A, which would be expected to ultimately induce the relaxation of airway smooth muscle. In conclusion, sinigrin enhances the asthma-relieving effects of beta-agonists by regulating the cAMP signaling pathway and represents a potential add-on drug to beta-agonists for the treatment of asthma.
- Journal
- Front Pharmacol
- Publish Year
- 2020
- Experiment Subject
- patient
- Experiment Type
- Cell Experiment
- Phenotype Related
- Acute-asthma; Asthma
- Paper Title Cn
- Paper Title En
- Sinigrin Enhanced Antiasthmatic Effects of Beta Adrenergic Receptors Agonists by Regulating cAMP-Mediated Pathways
- Bilingual Status
- semi_complete