ReferenceID 6196
Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial-mesenchymal transition and inflammation
Cell Death Dis
Idiopathic pulmonary fibrosis (IPF) is featured with inflammation and extensive lung remodeling caused by overloaded deposition of extracellular matrix. Scutellarin is the major effective ingredient of breviscapine and i
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Record Fields
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- Reference Id
- 6196
- Evidence Id
- 22786
- Core Evidence Id
- 22786
- Source Reference Id
- 5664
- Herb2 Reference Id
- HBREF006461
- Subject Paper Key
- HBIN043533_33188176
- Pubmed Id
- 33188176
- Doi
- 10.1038/s41419-020-03178-2
- Paper Title
- Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial-mesenchymal transition and inflammation
- Paper Abstract
- Idiopathic pulmonary fibrosis (IPF) is featured with inflammation and extensive lung remodeling caused by overloaded deposition of extracellular matrix. Scutellarin is the major effective ingredient of breviscapine and its anti-inflammation efficacy has been reported before. Nevertheless, the impact of scutellarin on IPF and the downstream molecular mechanism remain unclear. In this study, scutellarin suppressed BLM-induced inflammation via NF-kappaB/NLRP3 pathway both in vivo and in vitro. BLM significantly elevated p-p65/p65 ratio, IkappaBalpha degradation, and levels of NLRP3, caspase-1, caspase-11, ASC, GSDMDNterm, IL-1beta, and IL-18, while scutellarin reversed the above alterations except for that of caspase-11. Scutellarin inhibited BLM-induced epithelial-mesenchymal transition (EMT) process in vivo and in vitro. The expression levels of EMT-related markers, including fibronectin, vimentin, N-cadherin, matrix metalloproteinase 2 (MMP-2) and MMP-9, were increased in BLM group, and suppressed by scutellarin. The expression level of E-cadherin showed the opposite changes. However, overexpression of NLRP3 eliminated the anti-inflammation and anti-EMT functions of scutellarin in vitro. In conclusion, scutellarin suppressed inflammation and EMT in BLM-induced pulmonary fibrosis through NF-kappaB/NLRP3 signaling.
- Journal
- Cell Death Dis
- Publish Year
- 2020
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Idiopathic Pulmonary Fibrosis; Pulmonary Fibrosis; Inflammation
- Paper Title Cn
- Paper Title En
- Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial-mesenchymal transition and inflammation
- Bilingual Status
- semi_complete