ReferenceID 6160
Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response
Front Pharmacol
Mitochondria are essential organelles that perform important roles in cell biologies such as ATP synthesis, metabolic regulation, immunomodulatory, and apoptosis. Parkinson's disease (PD) is connected with mitochondrial
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Record Fields
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- Reference Id
- 6160
- Evidence Id
- 22750
- Core Evidence Id
- 22750
- Source Reference Id
- 5579
- Herb2 Reference Id
- HBREF006376
- Subject Paper Key
- HBIN042438_35652041
- Pubmed Id
- 35652041
- Doi
- 10.3389/fphar.2022.859978
- Paper Title
- Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response
- Paper Abstract
- Mitochondria are essential organelles that perform important roles in cell biologies such as ATP synthesis, metabolic regulation, immunomodulatory, and apoptosis. Parkinson's disease (PD) is connected with mitochondrial neuronal damage related to mitochondrial unfolded protein response (mtUPR). Rosmarinic acid (RA) is a naturally occurring hydroxylated polyphenolic chemical found in the Boraginaceae and the Labiatae subfamily Nepetoideae. This study looked into RA's protective effect against mitochondrial loss in the substantia nigra (SN) caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), the underlying mechanism associated with the mtUPR. Pretreatment with RA reduced motor impairments and dopaminergic neuronal degeneration in the SN of a mouse model injected with MPTP. Pretreatment of SH-SY5Y cells from cell viability loss, morphological damage, and oxidative stress. Furthermore, RA pre-injection suppressed MPTP-induced mtUPR, lowered the expression of HSPA9, HSPE1, CLPP, LONP1, and SIRT 4, and protected the MPTP-mice and SH-SY5Y cells from mitochondrial failure. These findings imply that RA can prevent Parkinson's disease by preventing mitochondrial damage in dopaminergic neurons in Parkinson's disease via alleviating mitochondrial unfolded protein response.
- Journal
- Front Pharmacol
- Publish Year
- 2022
- Experiment Subject
- mouse; sh-sy5y cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Mitochondrial Failure; Ra Reduced Motor Impairments; Dopaminergic Neuronal Degeneration; Mtupr; Parkinson's Disease
- Paper Title Cn
- Paper Title En
- Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response
- Bilingual Status
- semi_complete