ReferenceID 6137
The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders
Phytother Res
Rhamnazin (RN) is a flavonol isolated from the calyxes and fruits of Physalis alkekengi L. var. franchetii (Mast.) Makino, which has been used for treating pulmonary diseases in traditional Chinese medicine. The nuclear
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 6137
- Evidence Id
- 22727
- Core Evidence Id
- 22727
- Source Reference Id
- 5536
- Herb2 Reference Id
- HBREF006333
- Subject Paper Key
- HBIN042151_35129872
- Pubmed Id
- 35129872
- Doi
- 10.1002/ptr.7403
- Paper Title
- The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders
- Paper Abstract
- Rhamnazin (RN) is a flavonol isolated from the calyxes and fruits of Physalis alkekengi L. var. franchetii (Mast.) Makino, which has been used for treating pulmonary diseases in traditional Chinese medicine. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a therapeutic target for pulmonary diseases. In the present study, the underlying mechanism and pharmacological effect of RN against pulmonary disorders are investigated. Human lung epithelial Beas-2B cell and RAW 264.7 murine macrophage-based cell models, and a cigarette smoke (CS)-induced pulmonary impairment mice model are adopted for investigation in vitro and in vivo. RN is identified to be an Nrf2 activator, which promotes Nrf2 dissociation from Keap1 via reacting with the Cys151 cysteine residue of Keap1, and suppresses Nrf2 ubiquitination. In addition, RN is able to attenuate toxicant-stimulated oxidative stress and inflammatory response in vitro. Importantly, RN significantly relieves CS-induced oxidative insult and inflammation, and RN-induced inhibition of inflammation is related to inhibition of nuclear transcription factor-κB (NF-κB) and induction of cell autophagy. In conclusion, our data indicate that RN is an activator of the Nrf2 pathway and evidently alleviates pulmonary disorders via restricting NF-κB activation and promoting autophagy. RN is a promising candidate for the therapy of pulmonary disorders.
- Journal
- Phytother Res
- Publish Year
- 2022
- Experiment Subject
- mouse; human; human lung epithelial beas-2b cell; raw 264.7 murine macrophage-based cell models
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Pulmonary Disorders; Pulmonary Diseases; Inflammation
- Paper Title Cn
- Paper Title En
- The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders
- Bilingual Status
- semi_complete