ReferenceID 6134
Sulforaphene Suppresses Adipocyte Differentiation via Induction of Post-Translational Degradation of CCAAT/Enhancer Binding Protein Beta (C/EBPβ)
Nutrients
Adipocyte differentiation (adipogenesis) is a crucial process that determines the total number and size of mature adipocytes that will develop. In this study, the anti-adipogenic effect of sulforaphene (SFEN), a dietary
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 6134
- Evidence Id
- 22724
- Core Evidence Id
- 22724
- Source Reference Id
- 5530
- Herb2 Reference Id
- HBREF006327
- Subject Paper Key
- HBIN041943_32183002
- Pubmed Id
- 32183002
- Doi
- 10.3390/nu12030758
- Paper Title
- Sulforaphene Suppresses Adipocyte Differentiation via Induction of Post-Translational Degradation of CCAAT/Enhancer Binding Protein Beta (C/EBPβ)
- Paper Abstract
- Adipocyte differentiation (adipogenesis) is a crucial process that determines the total number and size of mature adipocytes that will develop. In this study, the anti-adipogenic effect of sulforaphene (SFEN), a dietary isothiocyanate (ITC) derived from radish, is investigated both in 3T3-L1 pre-adipocytes and in human adipose tissue-derived stem cells. The results revealed that SFEN significantly inhibit adipogenic cocktail-induced adipocyte differentiation and lipid accumulation at the early stage of adipogenesis. Additionally, the effects are more potent compared to those of other ITCs derived from various cruciferous vegetables. As a related molecular mechanism of action, SFEN promotes the post-translational degradation of CCAAT/enhancer-binding protein (C/EBP) beta by decreasing the stability of C/EBPbeta, which is responsible for decreasing the expression of master regulatory proteins such as peroxisome proliferator-activated receptor gamma and C/EBPalpha. Collectively, these results suggest that the intake of SFEN-enriched natural materials could be helpful as a strategy for preventing obesity.
- Journal
- Nutrients
- Publish Year
- 2020
- Experiment Subject
- human; 3t3-l1 pre-adipocytes; radish
- Experiment Type
- Cell Experiment
- Phenotype Related
- Obesity
- Paper Title Cn
- Paper Title En
- Sulforaphene Suppresses Adipocyte Differentiation via Induction of Post-Translational Degradation of CCAAT/Enhancer Binding Protein Beta (C/EBPβ)
- Bilingual Status
- semi_complete