ReferenceID 6056
Protocatechualdehyde attenuates obstructive nephropathy through inhibiting lncRNA9884 induced inflammation
Phytother Res
Persistent chronic inflammation and fibrosis product accumulation aggravate tubulointerstitial fibrosis (TIF), leading to the progression of chronic kidney disease. The aim of this study was designed to investigate the e
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 6056
- Evidence Id
- 22646
- Core Evidence Id
- 22646
- Source Reference Id
- 5374
- Herb2 Reference Id
- HBREF006171
- Subject Paper Key
- HBIN040905_33118280
- Pubmed Id
- 33118280
- Doi
- 10.1002/ptr.6919
- Paper Title
- Protocatechualdehyde attenuates obstructive nephropathy through inhibiting lncRNA9884 induced inflammation
- Paper Abstract
- Persistent chronic inflammation and fibrosis product accumulation aggravate tubulointerstitial fibrosis (TIF), leading to the progression of chronic kidney disease. The aim of this study was designed to investigate the effect of protocatechualdehyde (PCA), a natural phenolic acid compound isolated from Salvia miltiorrhiza, on the unilateral ureteral obstruction (UUO)-induced fibrosis and inflammation and to elucidate the underlying mechanism in primary renal tubular epithelial cells (TECs). Results from the histology suggested that the moderate to severe deteriorations of renal dysfunction and the pathological changes in UUO could be relieved by PCA treatment. Mechanistic studies revealed that the effect of PCA was associated with the downregulation of Smad3 and NF-kappaB driven fibrosis and inflammation respectively. It is worth noting that PCA could inhibit the aberrant expression of inflammation cytokines such as iNOS, MCP-1, TNF-alpha in UUO, and IL-1beta-treated TECs. In addition, PCA also suppressed the expression of Smad3-dependent long noncoding RNA (lncRNA), 9884. Importantly, when overexpressing of lncRNA9884 in TECs by transfection of pcDNA3.1-lncRNA9884 plasmid, it revealed significant reversal of protein expression levels as that observed with only PCA, suggesting that PCA inhibits inflammation by mediating lncRNA9884/MCP-1 signaling pathway. Collectively, the current study establishes a foundational basis for PCA in future treatment of obstructive nephropathy.
- Journal
- Phytother Res
- Publish Year
- 2021
- Experiment Subject
- uuo, and il-1beta-treated tecs
- Experiment Type
- Cell Experiment
- Phenotype Related
- Chronic Kidney Disease; Inflammation; Persistent Chronic Inflammation; Obstructive Nephropathy; Tubulointerstitial Fibrosis; Renal Dysfunction; Fibrosis; Unilateral Ureteral Obstruction
- Paper Title Cn
- Paper Title En
- Protocatechualdehyde attenuates obstructive nephropathy through inhibiting lncRNA9884 induced inflammation
- Bilingual Status
- semi_complete