ReferenceID 6039
Influence of Polydatin on the Tumor Microenvironment In Vitro: Studies with a Colon Cancer Cell Model
Int J Mol Sci
The tumor microenvironment of colon carcinoma, the site at which tumor cells and the host immune system interact, is influenced by signals from tumor cells, immunocompetent cells, and bacterial components, including LPS.
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Record Fields
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- Reference Id
- 6039
- Evidence Id
- 22629
- Core Evidence Id
- 22629
- Source Reference Id
- 5340
- Herb2 Reference Id
- HBREF006137
- Subject Paper Key
- HBIN040403_35955576
- Pubmed Id
- 35955576
- Doi
- 10.3390/ijms23158442
- Paper Title
- Influence of Polydatin on the Tumor Microenvironment In Vitro: Studies with a Colon Cancer Cell Model
- Paper Abstract
- The tumor microenvironment of colon carcinoma, the site at which tumor cells and the host immune system interact, is influenced by signals from tumor cells, immunocompetent cells, and bacterial components, including LPS. A large amount of LPS is available in the colon, and this could promote inflammation and metastasis by enhancing tumor cell adhesion to the endothelium. Polydatin (PD), the 3-β-D-glucoside of trans-resveratrol, is a polyphenol with anti-cancer, anti-inflammatory, and immunoregulatory effects. This study was designed to explore whether PD is able to produce antiproliferative effects on three colon cancer lines, to reduce the expression of adhesion molecules that are upregulated by LPS on endothelial cells, and to decrease the proinflammatory cytokines released in culture supernatants. Actually, we investigated the effects of PD on tumor growth in a coculture model with human mononuclear cells (MNCs) that mimics, at least in part, an in vitro tumor microenvironment. The results showed that PD alone or in combination with MNC exerts antiproliferative and proapoptotic effects on cancer cells, inhibits the production of the immunosuppressive cytokine IL-10 and of the proinflammatory cytokines upregulated by LPS, and reduces E-selectin and VCAM-1 on endothelial cells. These data provide preclinical support to the hypothesis that PD could be of potential benefit as a therapeutic adjuvant in colon cancer treatment and prevention.
- Journal
- Int J Mol Sci
- Publish Year
- 2022
- Experiment Subject
- human; colon cancer lines
- Experiment Type
- Cell Experiment
- Phenotype Related
- Colon Carcinoma; Cancer; Tumor; Colon Cancer
- Paper Title Cn
- Paper Title En
- Influence of Polydatin on the Tumor Microenvironment In Vitro: Studies with a Colon Cancer Cell Model
- Bilingual Status
- semi_complete