ReferenceID 6024
Hepatoprotective effect of piceatannol against carbon tetrachloride-induced liver fibrosis in mice
Food Funct
Piceatannol (3,5,3',4'-trans-tetrahydroxystilbene) is a natural analog and a metabolite of resveratrol present in grapes and red wine. Previous studies have reported that piceatannol exerts a broad spectrum of health ben
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Record Fields
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- Reference Id
- 6024
- Evidence Id
- 22614
- Core Evidence Id
- 22614
- Source Reference Id
- 5309
- Herb2 Reference Id
- HBREF006106
- Subject Paper Key
- HBIN040152_34676843
- Pubmed Id
- 34676843
- Doi
- 10.1039/d1fo02545g
- Paper Title
- Hepatoprotective effect of piceatannol against carbon tetrachloride-induced liver fibrosis in mice
- Paper Abstract
- Piceatannol (3,5,3',4'-trans-tetrahydroxystilbene) is a natural analog and a metabolite of resveratrol present in grapes and red wine. Previous studies have reported that piceatannol exerts a broad spectrum of health benefits including antioxidant, anti-inflammatory, chemopreventive, and neuroprotective effects. However, little is known about the hepatoprotective effect of piceatannol against toxin-induced liver fibrosis. Therefore, the objective of this study is to evaluate the protective effect of piceatannol in a mouse model of CCl4-induced hepatic fibrosis. Oral administration of piceatannol significantly improved the hepatic functions of CCl4-treated mice in both therapeutic and preventive models. Additionally, the immunohistochemical staining results revealed that collagen deposition in CCl4-injected mice was significantly reduced by treatment with piceatannol. Moreover, piceatannol remarkably suppressed the expressions of collagen I, alpha-smooth muscle protein (alpha-SMA), and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) induced by CCl4. The anti-fibrotic mechanism of piceatannol was associated with the regulation of the transforming growth factor-beta (TGF-beta)/Smad signaling pathway. Finally, piceatannol also profoundly alleviated CCl4-induced hepatic oxidative damage by elevating the level of glutathione and catalase activity. Altogether, our current findings suggest that piceatannol may serve as a bioactive agent that inhibits or alleviates toxic-induced fibroproliferative diseases, especially in the prevention of liver fibrosis.
- Journal
- Food Funct
- Publish Year
- 2021
- Experiment Subject
- mouse; grape
- Experiment Type
- Animal Experiment
- Phenotype Related
- Fibroproliferative Diseases; Liver Fibrosis; Hepatic Fibrosis; Toxin-induced Liver Fibrosis
- Paper Title Cn
- Paper Title En
- Hepatoprotective effect of piceatannol against carbon tetrachloride-induced liver fibrosis in mice
- Bilingual Status
- semi_complete