ReferenceID 6013
Protective Effects of Piperine on Ethanol-Induced Gastric Mucosa Injury by Oxidative Stress Inhibition
Nutrients
Piper nigrum Linnaeus is often used as a treatment for chills, stomach diseases, and other ailments. Piperine has many biological functions; however, its mechanism for preventing gastric mucosal damage is still unclear.
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 6013
- Evidence Id
- 22603
- Core Evidence Id
- 22603
- Source Reference Id
- 5287
- Herb2 Reference Id
- HBREF006084
- Subject Paper Key
- HBIN040071_36432431
- Pubmed Id
- 36432431
- Doi
- 10.3390/nu14224744
- Paper Title
- Protective Effects of Piperine on Ethanol-Induced Gastric Mucosa Injury by Oxidative Stress Inhibition
- Paper Abstract
- Piper nigrum Linnaeus is often used as a treatment for chills, stomach diseases, and other ailments. Piperine has many biological functions; however, its mechanism for preventing gastric mucosal damage is still unclear. The objective of this study was to investigate the preventive effects of piperine on ethanol-induced gastric mucosal injury by using GES-1 cells and rats. SOD, CAT, GSH-Px and MDA were effectively regulated in GES-1 cells pre-treated with piperine. Piperine significantly increased SOD, CAT and GSH-Px activities, but decreased the ulcer area, MDA, ROS and MPO levels in the gastric tissues of rats. RT-PCR analysis showed that piperine downregulated the mRNA expression levels of keap1, JNK, ERK and p38, and upregulated the mRNA transcription levels of Nrf2 and HO-1. Western blotting results indicated that piperine could activate the protein expression levels of Nrf2 and HO-1 and inhibit the protein expression levels of keap1, p -JNK, p -ERK and p -p38. In conclusion, piperine suppressed ethanol-induced gastric ulcers in vitro and in vivo via oxidation inhibition and improving gastric-protecting activity by regulating the Nrf2/HO-1 and MAPK signalling pathways.
- Journal
- Nutrients
- Publish Year
- 2022
- Experiment Subject
- rat; ges-1 cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Gastric Mucosal Damage; Chills; Gastric Mucosal Injury; Stomach Diseases; Gastric Ulcers
- Paper Title Cn
- Paper Title En
- Protective Effects of Piperine on Ethanol-Induced Gastric Mucosa Injury by Oxidative Stress Inhibition
- Bilingual Status
- semi_complete