ReferenceID 6005
Akt and calcium-permeable AMPA receptor are involved in the effect of pinoresinol on amyloid β-induced synaptic plasticity and memory deficits
Biochem Pharmacol
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders characterized by memory deficits. Although no drug has given promising results, synaptic dysfunction-modulating agents might be considered
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 6005
- Evidence Id
- 22595
- Core Evidence Id
- 22595
- Source Reference Id
- 5269
- Herb2 Reference Id
- HBREF006066
- Subject Paper Key
- HBIN040005_33310049
- Pubmed Id
- 33310049
- Doi
- 10.1016/j.bcp.2020.114366
- Paper Title
- Akt and calcium-permeable AMPA receptor are involved in the effect of pinoresinol on amyloid β-induced synaptic plasticity and memory deficits
- Paper Abstract
- Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders characterized by memory deficits. Although no drug has given promising results, synaptic dysfunction-modulating agents might be considered potential candidates for alleviating this disorder. Pinoresinol, a lignan found in Forsythia suspensa, is a memory-enhancing agent with excitatory synaptic activation. In the present study, we tested whether pinoresinol reduces learning and memory and excitatory synaptic deficits in an amyloid beta (Abeta)-induced AD-like mouse model. Pinoresinol enhanced hippocampal long-term potentiation (LTP) through calcium-permeable AMPA receptor, which was mediated by Akt activation. Moreover, pinoresinol ameliorated LTP deficits in amyloid beta (Abeta)-treated hippocampal slices via Akt signaling. Oral administration of pinoresinol ameliorated Abeta-induced memory deficits without sensory dysfunction. Moreover, AD-like pathology, including neuroinflammation and synaptic deficit, were ameliorated by pinoresinol administration. Collectively, pinoresinol may be a good candidate for AD therapy by modulating synaptic functions.
- Journal
- Biochem Pharmacol
- Publish Year
- 2021
- Experiment Subject
- mouse; amyloid beta (abeta)-induced ad-like mouse model
- Experiment Type
- Animal Experiment
- Phenotype Related
- Excitatory Synaptic Deficits; Alzheimer's Disease; Memory Deficits; Ad-like Pathology; Neuroinflammation And Synaptic Deficit; Sensory Dysfunction; Neurodegenerative Disorders; Abeta-induced Memory Deficits
- Paper Title Cn
- Paper Title En
- Akt and calcium-permeable AMPA receptor are involved in the effect of pinoresinol on amyloid β-induced synaptic plasticity and memory deficits
- Bilingual Status
- semi_complete