ReferenceID 599
Salvianolic acid A alleviates renal injury in systemic lupus erythematosus induced by pristane in BALB/c mice
Acta Pharm Sin B
The purpose of this study was to investigate the effects of salvianolic acid A (SAA) in systemic lupus erythematosus (SLE) induced by pristane in BALB/c mice. Lupus mice were established by confirming elevated levels of
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Reference: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final reference record.
- Reference Id
- 599
- Evidence Id
- 17189
- Core Evidence Id
- 17189
- Source Reference Id
- 1183
- Herb2 Reference Id
- HBREF001979
- Subject Paper Key
- HBIN042900_28303221
- Pubmed Id
- 28303221
- Doi
- 10.1016/j.apsb.2016.07.001
- Paper Title
- Salvianolic acid A alleviates renal injury in systemic lupus erythematosus induced by pristane in BALB/c mice
- Paper Abstract
- The purpose of this study was to investigate the effects of salvianolic acid A (SAA) in systemic lupus erythematosus (SLE) induced by pristane in BALB/c mice. Lupus mice were established by confirming elevated levels of autoantibodies and IL-6 after intraperitoneal injection of pristane. Mice were then treated with daily oral doses of SAA for 5 months in parallel with mice treated with prednisone and aspirin as positive controls. The levels of autoantibodies were monitored at monthly intervals and nephritic symptoms observed by hematoxylin and eosin (H&E) and periodic acid-Schiff (PAS) staining. Western blot analysis of renal tissue was also employed. SAA treatment caused a significant reduction in the levels of anti-Sm autoantibodies and reduced renal histopathological changes and pathological effects. SAA treatment also significantly inhibited the phosphorylation of IKK, IκB and NFκB in renal tissues of lupus mice. In conclusion, the results suggest that SAA alleviates renal injury in pristane-induced SLE in BALB/c mice through inhibition of phosphorylation of IKK, IκB and NFκB.
- Journal
- Acta Pharm Sin B
- Publish Year
- 2017
- Experiment Subject
- balb/c mice
- Experiment Type
- Animal Experiment
- Phenotype Related
- Systemic Lupus Erythematosus; Renal Injury
- Paper Title Cn
- Paper Title En
- Salvianolic acid A alleviates renal injury in systemic lupus erythematosus induced by pristane in BALB/c mice
- Bilingual Status
- semi_complete