ReferenceID 5938
Network Pharmacology-Based and Experimental Identification of the Effects of Paeoniflorin on Major Depressive Disorder
Front Pharmacol
Objective: Major depressive disorder (MDD) is one of the most common psychiatric disorders, the diagnosis and treatment of MDD are major clinical issues. However, there is a lack of effective biomarkers and drugs diagnos
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Record Fields
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- Reference Id
- 5938
- Evidence Id
- 22528
- Core Evidence Id
- 22528
- Source Reference Id
- 5136
- Herb2 Reference Id
- HBREF005933
- Subject Paper Key
- HBIN038606_35185541
- Pubmed Id
- 35185541
- Doi
- 10.3389/fphar.2021.793012
- Paper Title
- Network Pharmacology-Based and Experimental Identification of the Effects of Paeoniflorin on Major Depressive Disorder
- Paper Abstract
- Objective: Major depressive disorder (MDD) is one of the most common psychiatric disorders, the diagnosis and treatment of MDD are major clinical issues. However, there is a lack of effective biomarkers and drugs diagnosis and therapeutics of MDD. In the present study, bioinformatics analysis combined with an experimental verification strategy was used to identify biomarkers and paeoniflorin targets for MDD diagnosis and treatment. Methods: Based on network pharmacology, we obtained potential targets and pathways of paeoniflorin as an antidepressant through multiple databases. We then constructed a protein-protein interaction network and performed enrichment analyses. According to the results, we performed in vivo and in vitro experimental validation. Results: The results showed that paeoniflorin may exert an antidepressant effect by regulating cell inflammation, synaptic function, NF-kappaB signaling pathway, and intestinal inflammation. Conclusion: NPM1, HSPA8, HSPA5, HNRNPU, and TNF are the targets of paeoniflorin treatment. In addition, we demonstrated that paeoniflorin inhibits inflammatory cytokine production via the p38MAPK/NF-kappaB pathway and has neuroprotective effects on the synaptic structure. Our findings provide valuable evidence for the diagnosis and treatment of MDD.
- Journal
- Front Pharmacol
- Publish Year
- 2022
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Intestinal Inflammation; Major Depressive Disorder; Psychiatric Disorders
- Paper Title Cn
- Paper Title En
- Network Pharmacology-Based and Experimental Identification of the Effects of Paeoniflorin on Major Depressive Disorder
- Bilingual Status
- semi_complete