ReferenceID 5903
Oridonin prevents insulin resistance-mediated cognitive disorder through PTEN/Akt pathway and autophagy in minimal hepatic encephalopathy
J Cell Mol Med
Minimal hepatic encephalopathy (MHE) was characterized for cognitive dysfunction. Insulin resistance (IR) has been identified to be correlated with the pathogenesis of MHE. Oridonin (Ori) is an active terpenoid, which ha
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 5903
- Evidence Id
- 22493
- Core Evidence Id
- 22493
- Source Reference Id
- 5066
- Herb2 Reference Id
- HBREF005863
- Subject Paper Key
- HBIN038254_31568638
- Pubmed Id
- 31568638
- Doi
- 10.1111/jcmm.14546
- Paper Title
- Oridonin prevents insulin resistance-mediated cognitive disorder through PTEN/Akt pathway and autophagy in minimal hepatic encephalopathy
- Paper Abstract
- Minimal hepatic encephalopathy (MHE) was characterized for cognitive dysfunction. Insulin resistance (IR) has been identified to be correlated with the pathogenesis of MHE. Oridonin (Ori) is an active terpenoid, which has been reported to rescue synaptic loss and restore insulin sensitivity. In this study, we found that intraperitoneal injection of Ori rescued IR, reduced the autophagosome formation and synaptic loss and improved cognitive dysfunction in MHE rats. Moreover, in insulin-resistant PC12 cells and N2a cells, we found that Ori blocked IR-induced synaptic deficits via the down-regulation of PTEN, the phosphorylation of Akt and the inhibition of autophagy. Taken together, these results suggested that Ori displays therapeutic efficacy towards memory deficits via improvement of IR in MHE and represents a novel bioactive therapeutic agent for treating MHE.
- Journal
- J Cell Mol Med
- Publish Year
- 2020
- Experiment Subject
- rat; insulin-resistant pc12 cells; n2a cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Minimal Hepatic Encephalopathy; Cognitive Dysfunction
- Paper Title Cn
- Paper Title En
- Oridonin prevents insulin resistance-mediated cognitive disorder through PTEN/Akt pathway and autophagy in minimal hepatic encephalopathy
- Bilingual Status
- semi_complete