ReferenceID 5871
Nobiletin Inhibits Inflammatory Reaction in Interleukin-1β-Stimulated Human Periodontal Ligament Cells
Pharmaceutics
The immune response in periodontal lesions is involved in the progression of periodontal disease. Therefore, it is important to find a bioactive substance that has anti-inflammatory effects in periodontal lesions. This s
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- Reference Id
- 5871
- Evidence Id
- 22461
- Core Evidence Id
- 22461
- Source Reference Id
- 5008
- Herb2 Reference Id
- HBREF005805
- Subject Paper Key
- HBIN037171_34066937
- Pubmed Id
- 34066937
- Doi
- 10.3390/pharmaceutics13050667
- Paper Title
- Nobiletin Inhibits Inflammatory Reaction in Interleukin-1β-Stimulated Human Periodontal Ligament Cells
- Paper Abstract
- The immune response in periodontal lesions is involved in the progression of periodontal disease. Therefore, it is important to find a bioactive substance that has anti-inflammatory effects in periodontal lesions. This study aimed to examine if nobiletin, which is found in the peel of citrus fruits, could inhibit inflammatory responses in interleukin (IL)-1beta-stimulated human periodontal ligament cells (HPDLCs). The release of cytokines (IL-6, IL-8, CXCL10, CCL20, and CCL2) and matrix metalloproteinases (MMP-1 and MMP-3) was assessed by ELISA. The expression of cell adhesion molecules (ICAM-1and VCAM-1) and the activation of signal transduction pathways (nuclear factor (NF)-kappaB, mitogen-activated protein kinases (MAPKs) and protein kinase B (Akt)) in HPDLCs were detected by Western blot analysis. Our experiments revealed that nobiletin decreased the expression of inflammatory cytokines, cell adhesion molecules, and MMPs in IL-1beta-stimulated HPDLCs. Moreover, we revealed that nobiletin treatment could suppress the activation of the NF-kappaB, MAPKs, and Akt pathways. These findings indicate that nobiletin could inhibit inflammatory reactions in IL-1beta-stimulated HPDLCs by inhibiting multiple signal transduction pathways, including NF-kappaB, MAPKs, and Akt.
- Journal
- Pharmaceutics
- Publish Year
- 2021
- Experiment Subject
- human; il-1beta-stimulated hpdlcs; interleukin (il)-1beta-stimulated human periodontal ligament cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Periodontal Lesions; Periodontal Disease
- Paper Title Cn
- Paper Title En
- Nobiletin Inhibits Inflammatory Reaction in Interleukin-1β-Stimulated Human Periodontal Ligament Cells
- Bilingual Status
- semi_complete