ReferenceID 5840
Naringin Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension Through Endothelial-To-Mesenchymal Transition Inhibition
Front Pharmacol
Pulmonary arterial hypertension (PAH) caused by enhanced arterial pressure increases vessel resistance in the lung. Endothelial-to-mesenchymal transition (EndMT) plays key roles in the vascular remodeling in PAH. Naringi
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Record Fields
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- Reference Id
- 5840
- Evidence Id
- 22430
- Core Evidence Id
- 22430
- Source Reference Id
- 4933
- Herb2 Reference Id
- HBREF005730
- Subject Paper Key
- HBIN036380_34335261
- Pubmed Id
- 34335261
- Doi
- 10.3389/fphar.2021.696135
- Paper Title
- Naringin Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension Through Endothelial-To-Mesenchymal Transition Inhibition
- Paper Abstract
- Pulmonary arterial hypertension (PAH) caused by enhanced arterial pressure increases vessel resistance in the lung. Endothelial-to-mesenchymal transition (EndMT) plays key roles in the vascular remodeling in PAH. Naringin, a protective gaseous mediator is commonly extracted from tomatoes and citrus fruits (such as grapefruits), and demonstrates anti-inflammation, anti-oxidant, anti-proliferation, and anti-tumor effects. Meanwhile, the association of Naringin and the process of EndMT is still unclear. In this study, monocrotaline (MCT) administration (60 mg/kg) was delivered for the induction of PAH in rats. Following this, Naringin (concentrations: 25, 50, and 100 mg/kg/day) was used for treatments. Human Umbilical Vein Endothelial Cells (HUVECs) were stimulated with Naringin and transforming growth factor beta1 (TGFbeta1, 10 ng/ml). As the result, Naringin was demonstrated to inhibit EndMT and alleviate PAH progression. In particular, in HUVECs, Naringin significantly suppressed the mesenchymal marker expression induced by TGFbeta1 treatment, enhanced the endothelial marker expression, and inhibited the activation of ERK and NF-kappaB signaling pathways. To conclude, this study provided novel evidence suggesting the beneficial effects of Naringin in PAH through the inhibition of the ERK and NF-kappaB signaling pathways and the EndMT progression in pulmonary arteries.
- Journal
- Front Pharmacol
- Publish Year
- 2021
- Experiment Subject
- rat; human; human umbilical vein endothelial cells; huvecs; tomatoe
- Experiment Type
- Cell Experiment
- Phenotype Related
- Pulmonary Arterial Hypertension; Pulmonary Arteries; Endmt
- Paper Title Cn
- Paper Title En
- Naringin Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension Through Endothelial-To-Mesenchymal Transition Inhibition
- Bilingual Status
- semi_complete