ReferenceID 5817
Multiple modes of action of myricetin in influenza A virus infection
Phytother Res
Influenza A virus remains a major threat to public health worldwide after its first pandemic. Scientists keep searching novel anti-influenza drugs, of which natural products present to be an important source. Myricetin,
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- Reference Id
- 5817
- Evidence Id
- 22407
- Core Evidence Id
- 22407
- Source Reference Id
- 4888
- Herb2 Reference Id
- HBREF005685
- Subject Paper Key
- HBIN036092_33484023
- Pubmed Id
- 33484023
- Doi
- 10.1002/ptr.7025
- Paper Title
- Multiple modes of action of myricetin in influenza A virus infection
- Paper Abstract
- Influenza A virus remains a major threat to public health worldwide after its first pandemic. Scientists keep searching novel anti-influenza drugs, of which natural products present to be an important source. Myricetin, a natural flavonol compound, which exists in many edible plants, which has a wide range of biological activities, but its anti-influenza A virus activity is ambiguous. This study aims to evaluate the anti-influenza activity of myricetin and elucidate its underlying mechanism. Our results demonstrated that myricetin could significantly inhibit influenza A virus replication, reduce viral polymerase activity via selective inhibition of viral PB2 subunit, and the production of inflammatory cytokines by inhibiting TLR3 signaling pathway. The binding affinity analysis and the result of molecular docking revealed that myricetin interacted with the PB2 cap-binding pocket of influenza A virus. The above results suggested myricetin could exhibit anti-influenza virus activity with low cytotoxicity as well, and myricetin had low toxicity in BALB/c mice in vivo. Results from this study highlighted myricetin could be considered as a promising anti-influenza virus agent with dual inhibition profile. Furthermore, the compound with similar structure would provide a new option for the development of novel inhibitors against influenza A virus.
- Journal
- Phytother Res
- Publish Year
- 2021
- Experiment Subject
- mouse; influenza
- Experiment Type
- Animal Experiment
- Phenotype Related
- Influenza
- Paper Title Cn
- Paper Title En
- Multiple modes of action of myricetin in influenza A virus infection
- Bilingual Status
- semi_complete