ReferenceID 5770
Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy
Inflammopharmacology
Gout is a chronic disease caused by monosodium urate (MSU) crystal deposition in the joints and surrounding tissues. We examined the effects of Taxifolin, a natural flavonoid mainly existing in vegetables and fruits, on
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Record Fields
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- Reference Id
- 5770
- Evidence Id
- 22360
- Core Evidence Id
- 22360
- Source Reference Id
- 5895
- Herb2 Reference Id
- HBREF006692
- Subject Paper Key
- HBIN045672_35708797
- Pubmed Id
- 35708797
- Doi
- 10.1007/s10787-022-01014-x
- Paper Title
- Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy
- Paper Abstract
- Gout is a chronic disease caused by monosodium urate (MSU) crystal deposition in the joints and surrounding tissues. We examined the effects of Taxifolin, a natural flavonoid mainly existing in vegetables and fruits, on MSU-induced gout. Pretreatment with Taxifolin significantly reduced IL-1β, Caspase-1 and HMGB1 levels, upregulation of autophagy-related protein, LC3, as well as improved phagocytosis of macrophages. This study indicated that Taxifolin-attenuated inflammatory response in MSU-induced acute gout model by decreasing pro-inflammatory cytokine production and promoting the autophagy and phagocytic capacity of macrophages. Dietary supplementation with Taxifolin induces the autophagy and attenuated inflammatory response, which in consequence modulates acute gout. A preventive strategy combining dietary interventions with Taxifolin may offer a potential therapeutic alternative to pharmacological treatment to reduce inflammatory response to gout.
- Journal
- Inflammopharmacology
- Publish Year
- 2022
- Experiment Subject
- Experiment Type
- Animal Experiment
- Phenotype Related
- Chronic Disease; Gout; Acute Gout
- Paper Title Cn
- Paper Title En
- Taxifolin blocks monosodium urate crystal-induced gouty inflammation by regulating phagocytosis and autophagy
- Bilingual Status
- semi_complete