ReferenceID 5687
Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
Front Pharmacol
Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens , has a good anti-leukemia effect, but its key target and mechanism remains unclear. Here, we found that only c-Myc
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Record Fields
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- Reference Id
- 5687
- Evidence Id
- 22277
- Core Evidence Id
- 22277
- Source Reference Id
- 4621
- Herb2 Reference Id
- HBREF005418
- Subject Paper Key
- HBIN034558_36339620
- Pubmed Id
- 36339620
- Doi
- 10.3389/fphar.2022.1027441
- Paper Title
- Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
- Paper Abstract
- Previous studies have shown that matrine, a natural compound extracted from the herb Sophora flavescens , has a good anti-leukemia effect, but its key target and mechanism remains unclear. Here, we found that only c-Myc could respond rapidly to matrine treatment in three myeloid leukemia cell lines, and matrine inhibited both transcription and translation of c-Myc. Ribosome biogenesis and nucleotide metabolism, the key downstream of c-Myc, were significantly suppressed after matrine treatment. Therefore, our results confirmed that matrine is a special c-Myc inhibitor which suppresses ribosome biogenesis and nucleotide metabolism by inhibiting c-Myc in myeloid leukemia. This study provides scientific basis for the development of matrine derivatives to c-Myc-driven cancers.
- Journal
- Front Pharmacol
- Publish Year
- 2022
- Experiment Subject
- myeloid leukemia cell lines
- Experiment Type
- Cell Experiment
- Phenotype Related
- C-myc-driven Cancers; Myeloid Leukemia
- Paper Title Cn
- Paper Title En
- Matrine, a potential c-Myc inhibitor, suppresses ribosome biogenesis and nucleotide metabolism in myeloid leukemia
- Bilingual Status
- semi_complete