ReferenceID 5677
Ingestion of mannose ameliorates thioacetamide-induced intrahepatic oxidative stress, inflammation and fibrosis in rats
Life Sci
BACKGROUND AND AIMS: The monosaccharide mannose has gained recent interest for its beneficial effect against certain inflammatory disorders. Nevertheless, the influence of mannose on experimentally-induced liver fibrosis
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- Reference Id
- 5677
- Evidence Id
- 22267
- Core Evidence Id
- 22267
- Source Reference Id
- 4597
- Herb2 Reference Id
- HBREF005394
- Subject Paper Key
- HBIN034421_34637794
- Pubmed Id
- 34637794
- Doi
- 10.1016/j.lfs.2021.120040
- Paper Title
- Ingestion of mannose ameliorates thioacetamide-induced intrahepatic oxidative stress, inflammation and fibrosis in rats
- Paper Abstract
- BACKGROUND AND AIMS: The monosaccharide mannose has gained recent interest for its beneficial effect against certain inflammatory disorders. Nevertheless, the influence of mannose on experimentally-induced liver fibrosis and the ensued inflammation is still not fully clear to date. MAIN METHODS: The current study investigated the outcomes of treating rats with mannose (0.2 ml of 20% w/v, oral gavage) 30 min before the twice weekly intoxication with thioacetamide (TAA) (200 mg/kg, intraperitoneal) for a total period of 8 weeks. KEY FINDINGS: The data indicated that mannose markedly dampened TAA-induced liver fibrosis, as indicated by lowering the fibrotic bridges shown by Masson's trichrome staining. This effect was consistent with reducing TAA-induced hepatocellular injury, as evidenced biochemically (serum ALT and AST activities) and pathologically (necroinflammation score). These hepatoprotective effects mediated by mannose were attributed to i) reversing TAA-induced rise in malondialdehyde (MDA) and decrease in reduced glutathione (GSH) expressions in the liver, ii) limiting TAA-induced release of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), iii) impairing TAA-induced activation of hepatic stellate cells by downregulating alpha-smooth muscle actin expression (alpha-SMA), and more importantly, iv) dampening TAA-induced fibrogenesis driven by transforming growth factor-beta1 (TGF-beta1) and connective tissue growth factor (CTGF). SIGNIFICANCE: Mannose may be a valuable candidate for preventing oxidative stress, inflammation and fibrogenesis in the liver.
- Journal
- Life Sci
- Publish Year
- 2021
- Experiment Subject
- rat
- Experiment Type
- Animal Experiment
- Phenotype Related
- Inflammation; Liver Fibrosis; Hepatocellular Injury; Inflammatory Disorders; Fibrogenesis
- Paper Title Cn
- Paper Title En
- Ingestion of mannose ameliorates thioacetamide-induced intrahepatic oxidative stress, inflammation and fibrosis in rats
- Bilingual Status
- semi_complete