ReferenceID 5669
Mangiferin protects against alcoholic liver injury via suppression of inflammation-induced adipose hyperlipolysis
Food Funct
Adipose dysfunction is closely associated with alcoholic liver disease. The impact of mangiferin on ethanol-induced liver injury and the probable underlying molecular mechanism has not been sufficiently addressed. In the
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Record Fields
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- Reference Id
- 5669
- Evidence Id
- 22259
- Core Evidence Id
- 22259
- Source Reference Id
- 4586
- Herb2 Reference Id
- HBREF005383
- Subject Paper Key
- HBIN034394_32969440
- Pubmed Id
- 32969440
- Doi
- 10.1039/d0fo01436b
- Paper Title
- Mangiferin protects against alcoholic liver injury via suppression of inflammation-induced adipose hyperlipolysis
- Paper Abstract
- Adipose dysfunction is closely associated with alcoholic liver disease. The impact of mangiferin on ethanol-induced liver injury and the probable underlying molecular mechanism has not been sufficiently addressed. In the present study, mice were subjected to a chronic plus a single binge ethanol feeding to induce liver injury. In addition, the differentiated adipocytes from primary mouse adipocytes were isolated and used for the mechanism studies. Our study demonstrated that mangiferin protects against ethanol induced adipose hyperlipolysis by restoring PDE3B stability, which is associated with activating the AMPK/TBK1 signaling and suppressing the noncanonical NF-kappaB activation, leading to the reduction of free fatty acid release and the amelioration of ethanol-induced liver injury. Our findings identify that mangiferin ameliorates alcoholic liver injury via suppression of inflammation-induced adipose hyperlipolysis, suggesting that mangiferin might be a potential effective agent for the management of alcoholic liver injury.
- Journal
- Food Funct
- Publish Year
- 2020
- Experiment Subject
- mouse
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Alcoholic Liver Disease; Alcoholic Liver Injury; Ethanol-induced Liver Injury; Adipose Dysfunction; Liver Injury
- Paper Title Cn
- Paper Title En
- Mangiferin protects against alcoholic liver injury via suppression of inflammation-induced adipose hyperlipolysis
- Bilingual Status
- semi_complete