ReferenceID 5654
Lycopene attenuates oxidative stress-induced hepatic dysfunction of insulin signal transduction: involvement of FGF21 and mitochondria
J Nutr Biochem
Lycopene (LYC) has been regarded as a nutraceutical that has powerful antioxidant and hepatoprotective bioactivities. In the present study, we aimed to investigate the beneficial effects of LYC on hepatic insulin signal
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Record Fields
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- Reference Id
- 5654
- Evidence Id
- 22244
- Core Evidence Id
- 22244
- Source Reference Id
- 4539
- Herb2 Reference Id
- HBREF005336
- Subject Paper Key
- HBIN033972_36057413
- Pubmed Id
- 36057413
- Doi
- 10.1016/j.jnutbio.2022.109144
- Paper Title
- Lycopene attenuates oxidative stress-induced hepatic dysfunction of insulin signal transduction: involvement of FGF21 and mitochondria
- Paper Abstract
- Lycopene (LYC) has been regarded as a nutraceutical that has powerful antioxidant and hepatoprotective bioactivities. In the present study, we aimed to investigate the beneficial effects of LYC on hepatic insulin signal transduction under oxidative stress conditions and the possible involvement of FGF21 and mitochondria pathways. Two-month-old CD-1 mice were treated by intraperitoneal injection of D-galactose (D-gal) 150 mg/kg/day for 8 weeks and received 0.03% LYC (w/w, mixed into diet). The results showed that LYC increased the expression of FGF21, alleviated mitochondrial dysfunction and improved hepatic insulin signal transduction in D-gal-treated mice. Furthermore, knockdown of FGF21 by small interfering RNA notably suppressed mitochondrial function and blunted LYC-stimulated insulin signal transduction in H 2 O 2 -treated HepG2 cells. Moreover, suppressed mitochondrial function via oligomycin also inhibited insulin signal transduction, indicating that LYC supplementation ameliorated oxidative stress-induced hepatic dysfunction of insulin signal transduction by up-regulating FGF21 and enhancing mitochondrial function.
- Journal
- J Nutr Biochem
- Publish Year
- 2022
- Experiment Subject
- mouse; h 2 o 2 -treated hepg2 cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Mitochondrial Dysfunction
- Paper Title Cn
- Paper Title En
- Lycopene attenuates oxidative stress-induced hepatic dysfunction of insulin signal transduction: involvement of FGF21 and mitochondria
- Bilingual Status
- semi_complete