ReferenceID 5651
AQP2 as a target of lycopene protects against atrazine-induced renal ionic homeostasis disturbance
Food Funct
Atrazine (ATR), a ubiquitous environmental contaminant in water and soil, causes environmental nephrosis. To reveal the toxic effect of ATR on the kidney and the potential chemical nephroprotective effect of lycopene (LY
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 5651
- Evidence Id
- 22241
- Core Evidence Id
- 22241
- Source Reference Id
- 4530
- Herb2 Reference Id
- HBREF005327
- Subject Paper Key
- HBIN033972_33960999
- Pubmed Id
- 33960999
- Doi
- 10.1039/d0fo03214j
- Paper Title
- AQP2 as a target of lycopene protects against atrazine-induced renal ionic homeostasis disturbance
- Paper Abstract
- Atrazine (ATR), a ubiquitous environmental contaminant in water and soil, causes environmental nephrosis. To reveal the toxic effect of ATR on the kidney and the potential chemical nephroprotective effect of lycopene (LYC), Kun-Ming mice of specific pathogen-free (SPF) grade were treated with LYC (5 mg kg-1) and/or ATR (50 mg kg-1 or 200 mg kg-1) for 21 days. The degree of renal injury was evaluated by measuring the ion concentration, ATPase activities and the mRNA expressions/levels of associated ATPase subunits. In addition, the expression of renal aquaporins (AQPs) was analyzed. The results showed that the renal tubular epithelial cells of ATR-exposed mice were swollen, the glomeruli were significantly atrophied, and the ion concentrations were obviously changed. The activity of Na+-K+-ATPase and the transcription of its subunits were downregulated. The activity of Ca2+-Mg2+-ATPase and the transcription of its subunits were upregulated. The expression of AQPs, especially the critical AQP2, was affected. Notably, ATR-induced nephrotoxicity was significantly improved by LYC supplementation. Therefore, LYC could protect the kidney against ATR-induced nephrotoxicity via maintaining ionic homeostasis, reversing the changes in ATPase activity and controlling the expression of AQPs on the cell membrane. These results suggested that AQP2 was a target of LYC and protected against ATR-induced renal ionic homeostasis disturbance.
- Journal
- Food Funct
- Publish Year
- 2021
- Experiment Subject
- mouse
- Experiment Type
- Animal Experiment
- Phenotype Related
- Nephrosis; Renal Injury
- Paper Title Cn
- Paper Title En
- AQP2 as a target of lycopene protects against atrazine-induced renal ionic homeostasis disturbance
- Bilingual Status
- semi_complete