ReferenceID 5648
Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice
J Nutr Biochem
Lycopene (LYC), one of the major carotenoids in tomatoes, has been preclinically and clinically used to obesity and type 2 diabetes management. However, whether its ability of countering body weight gain is related to in
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- Reference Id
- 5648
- Evidence Id
- 22238
- Core Evidence Id
- 22238
- Source Reference Id
- 4524
- Herb2 Reference Id
- HBREF005321
- Subject Paper Key
- HBIN033972_31978713
- Pubmed Id
- 31978713
- Doi
- 10.1016/j.jnutbio.2019.108335
- Paper Title
- Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice
- Paper Abstract
- Lycopene (LYC), one of the major carotenoids in tomatoes, has been preclinically and clinically used to obesity and type 2 diabetes management. However, whether its ability of countering body weight gain is related to induction of brown-like adipocyte phenotype in white adipose tissues (WAT) remains largely unknown. Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) serves the brown-like phenotype conversion and energy expenditure. Here, we show that LYC treatment promotes glucose consumption and improves insulin sensitivity, as well as fosters white adipocytes browning through up-regulating mRNA and protein expression levels of PPARgamma, uncoupling protein 1, PPARgamma coactivator-1alpha and PR domain-containing 16 in the differentiated 3T3-L1 adipocytes and primary adipocytes, as well as in the WAT of HFD-exposed obese mice. In addition, LYC treatment attenuates body weight gain and improves serum lipid profiles as well as promotes brown adipose tissue activation in obese mice. Moreover, PPARgamma is induced with LYC intervention in mitochondria respiration and browning in white adipocytes and tissues. Taken together, these results suggest that LYC counteracts obesity and improves glucose and lipid metabolism through induction of the browning via up-regulation of PPARgamma, which offers a new perspective of this compound to combat obesity and obesity-related disorders.
- Journal
- J Nutr Biochem
- Publish Year
- 2020
- Experiment Subject
- mouse; differentiated 3t3-l1 adipocytes; tomatoe
- Experiment Type
- Animal Experiment
- Phenotype Related
- Obesity; Type 2 Diabetes; Obese
- Paper Title Cn
- Paper Title En
- Lycopene attenuates body weight gain through induction of browning via regulation of peroxisome proliferator-activated receptor γ in high-fat diet-induced obese mice
- Bilingual Status
- semi_complete