ReferenceID 5621
Saikosaponin A, a Triterpene Saponin, Suppresses Angiogenesis and Tumor Growth by Blocking VEGFR2-Mediated Signaling Pathway
Front Pharmacol
Saikosaponin A (SSA), a main triterpenoid saponin component from Radix Bupleurum, has been revealed to have a variety of pharmacological activities. However, whether SSA can inhibit angiogenesis, a key step in solid tumo
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 5621
- Evidence Id
- 22211
- Core Evidence Id
- 22211
- Source Reference Id
- 5603
- Herb2 Reference Id
- HBREF006400
- Subject Paper Key
- HBIN042787_34776948
- Pubmed Id
- 34776948
- Doi
- 10.3389/fphar.2021.713200
- Paper Title
- Saikosaponin A, a Triterpene Saponin, Suppresses Angiogenesis and Tumor Growth by Blocking VEGFR2-Mediated Signaling Pathway
- Paper Abstract
- Saikosaponin A (SSA), a main triterpenoid saponin component from Radix Bupleurum, has been revealed to have a variety of pharmacological activities. However, whether SSA can inhibit angiogenesis, a key step in solid tumor progression, remains unknown. In this study, we demonstrated that SSA could powerfully suppress the proliferation, migration, and tube formation of human umbilical vein endothelial cells. SSA also significantly inhibited angiogenesis in the models of the chick embryo chorioallantoic membrane and Matrigel plugs. Moreover, SSA was found to inhibit tumor growth in both orthotopic 4T1 breast cancer and subcutaneous HCT-15 colorectal tumor by the inhibition of tumor angiogenesis. Western blot assay indicated the antiangiogenic mechanism of SSA in the suppression of the protein phosphorylation of VEGFR2 and the downstream protein kinase including PLCgamma1, FAK, Src, and Akt. In summary, SSA can suppress angiogenesis and tumor growth by blocking the VEGFR2-mediated signaling pathway.
- Journal
- Front Pharmacol
- Publish Year
- 2021
- Experiment Subject
- human; chick
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Tumor; Solid Tumor; Orthotopic 4t1 Breast Cancer; Subcutaneous Hct-15 Colorectal Tumor
- Paper Title Cn
- Paper Title En
- Saikosaponin A, a Triterpene Saponin, Suppresses Angiogenesis and Tumor Growth by Blocking VEGFR2-Mediated Signaling Pathway
- Bilingual Status
- semi_complete