ReferenceID 5616
Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats
Cells
Loganin is an iridoid glycoside with antioxidant, anti-inflammatory, glucose-lowering activities which may address the pathological mechanisms of painful diabetic neuropathy (PDN) related to inflammation, oxidative stres
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Record Fields
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- Reference Id
- 5616
- Evidence Id
- 22206
- Core Evidence Id
- 22206
- Source Reference Id
- 4459
- Herb2 Reference Id
- HBREF005256
- Subject Paper Key
- HBIN033476_34685668
- Pubmed Id
- 34685668
- Doi
- 10.3390/cells10102688
- Paper Title
- Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats
- Paper Abstract
- Loganin is an iridoid glycoside with antioxidant, anti-inflammatory, glucose-lowering activities which may address the pathological mechanisms of painful diabetic neuropathy (PDN) related to inflammation, oxidative stress, and hyperglycemia. This study investigated the underlying mechanisms of action of loganin on PDN. The in vivo model of PDN was established by streptozotocin-nicotinamide (STZ-NA) induction in Sprague Dawley (SD) rats. Subsequently, loganin (5 mg/kg) was administered by daily intraperitoneal injection. High-glucose stimulated human SH-SY5Y cells co-incubated with loganin were used to mimic the in vitro model of PDN. Loganin improved PDN rats' associated pain behaviors (allodynia and hyperalgesia), insulin resistance index (HOMA-IR), and serum levels of superoxide dismutase (SOD), catalase and glutathione. Loganin also reduced pain-associated channel protein CaV3.2 and calcitonin gene-related peptide (CGRP) in the surficial spinal dorsal horn of PDN rats. Loganin inhibited oxidative stress and NF-kappaB activation and decreased the levels of mRNA and protein of proinflammatory factors IL-1beta and TNF-alpha. Moreover, loganin attenuated insulin resistance by modulating the JNK-IRS-1 (insulin receptor substrate-1)-Akt-GSK3beta signaling pathway in PDN rats. These results suggested that loganin improved PDN-mediated pain behaviors by inhibiting oxidative stress-provoked inflammation in the spinal cord, resulting in improved neuropathic pain.
- Journal
- Cells
- Publish Year
- 2021
- Experiment Subject
- rat; human; high-glucose stimulated human sh-sy5y cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Painful Diabetic Neuropathy; Inflammation; Allodynia; Hyperglycemia; Hyperalgesia; Neuropathic Pain
- Paper Title Cn
- Paper Title En
- Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats
- Bilingual Status
- semi_complete