ReferenceID 5597
Fangchinoline abrogates growth and survival of hepatocellular carcinoma by negative regulation of c-met/HGF and its associated downstream signaling pathways
Phytother Res
Among all cancers, hepatocellular carcinoma (HCC) remains a lethal disease with limited treatment options. In this study, we have analyzed the possible inhibitory effects of Fangchinoline (FCN) on c-Met, a protein known
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Record Fields
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- Reference Id
- 5597
- Evidence Id
- 22187
- Core Evidence Id
- 22187
- Source Reference Id
- 4428
- Herb2 Reference Id
- HBREF005225
- Subject Paper Key
- HBIN033231_35867025
- Pubmed Id
- 35867025
- Doi
- 10.1002/ptr.7573
- Paper Title
- Fangchinoline abrogates growth and survival of hepatocellular carcinoma by negative regulation of c-met/HGF and its associated downstream signaling pathways
- Paper Abstract
- Among all cancers, hepatocellular carcinoma (HCC) remains a lethal disease with limited treatment options. In this study, we have analyzed the possible inhibitory effects of Fangchinoline (FCN) on c-Met, a protein known to regulate the rapid phosphorylation of downstream signals, as well as mediate aberrant growth, metastasis, survival, and motility in cancer. FCN inhibited the activation of c-Met and its downstream signals PI3K, AKT, mTOR, MEK, and ERK under in vitro settings. Moreover, c-Met gene silencing lead to suppression of PI3K/AKT/mTOR and MEK/ERK signaling pathways, and induced apoptotic cell death upon exposure to FCN. In addition, FCN markedly inhibited the expression of the various oncogenic proteins such as Bcl-2/xl, survivin, IAP-1/2, cyclin D1, and COX-2. In vivo studies in HepG2 cells xenograft mouse model showed that FCN could significantly attenuate the tumor volume and weight, without affecting significant loss in the body weight. Similar to in vitro studies, expression level of c-Met and PI3K/AKT/mTOR, MEK/ERK signals was also suppressed by FCN in the tissues obtained from mice. Therefore, the novel findings of this study suggest that FCN can potentially function as a potent anticancer agent against HCC.
- Journal
- Phytother Res
- Publish Year
- 2022
- Experiment Subject
- mouse; hepg2 cells
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Cancers; Hepatocellular Carcinoma; Tumor; Cancer
- Paper Title Cn
- Paper Title En
- Fangchinoline abrogates growth and survival of hepatocellular carcinoma by negative regulation of c-met/HGF and its associated downstream signaling pathways
- Bilingual Status
- semi_complete