ReferenceID 5575
Vitamin C promotes anti-leukemia of DZNep in acute myeloid leukemia
Biochim Biophys Acta Mol Basis Dis
The epigenetic treatment by 3-Deazaneplanocin A (DZNep), a histone methyltransferase inhibitor, shows great potential against acute myeloid leukemia (AML). However, the variant sensitivity and incomplete response to DZNe
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Record Fields
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- Reference Id
- 5575
- Evidence Id
- 22165
- Core Evidence Id
- 22165
- Source Reference Id
- 4370
- Herb2 Reference Id
- HBREF005167
- Subject Paper Key
- HBIN032689_35143932
- Pubmed Id
- 35143932
- Doi
- 10.1016/j.bbadis.2022.166357
- Paper Title
- Vitamin C promotes anti-leukemia of DZNep in acute myeloid leukemia
- Paper Abstract
- The epigenetic treatment by 3-Deazaneplanocin A (DZNep), a histone methyltransferase inhibitor, shows great potential against acute myeloid leukemia (AML). However, the variant sensitivity and incomplete response to DZNep are commonly observed. Here, we reveal that vitamin C (Vc) dramatically promotes DZNep response against leukemic cells in different cell lines and primary AML samples. Vc enhances apoptosis and differentiation induced by DZNep in different AML cell lines in vitro and reduces leukemia progression in vivo. At the molecular level, Vc downregulates an enzyme of serine synthesis named D-3-phosphoglycerate dehydrogenase (PHGDH), as well as BCL2, an anti-apoptotic gene. Over-expression of PHGDH reverses the Vc-enhanced anti-leukemic effect of DZNep in AML cells. Therefore, our findings provide an effective approach to reduce the resistance against epigenetic treatment by Vc, which shows a potential improvement of their combination in AML patients.
- Journal
- Biochim Biophys Acta Mol Basis Dis
- Publish Year
- 2022
- Experiment Subject
- patient; aml cell lines
- Experiment Type
- Cell Experiment
- Phenotype Related
- Leukemic; Acute Myeloid Leukemia; Leukemia
- Paper Title Cn
- Paper Title En
- Vitamin C promotes anti-leukemia of DZNep in acute myeloid leukemia
- Bilingual Status
- semi_complete