ReferenceID 5553
Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways
Geroscience
Compounds with lifespan extension activity are rare, although increasing research efforts have been invested in this field to find ways to extend healthy lifespan. By applying a yeast-based high-throughput assay to ident
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 5553
- Evidence Id
- 22143
- Core Evidence Id
- 22143
- Source Reference Id
- 4330
- Herb2 Reference Id
- HBREF005127
- Subject Paper Key
- HBIN032423_36462128
- Pubmed Id
- 36462128
- Doi
- 10.1007/s11357-022-00693-2
- Paper Title
- Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways
- Paper Abstract
- Compounds with lifespan extension activity are rare, although increasing research efforts have been invested in this field to find ways to extend healthy lifespan. By applying a yeast-based high-throughput assay to identify the chronological lifespan extension activity of mulberry extracts rapidly, we demonstrated that a group of prenylated flavones, particularly morusin and mulberrin, could extend the chronological lifespan of budding yeast via a nutrient-dependent regime by at least partially targeting SCH9. Their antiaging activity could be extended to C. elegans by promoting its longevity, dependent on the full functions of genes akt-1 or akt-2. Moreover, additional benefits were observed from morusin- and mulberrin-treated worms, including increased reproduction without the influence of worm health (pumping rate, pumping decline, and reproduction span). In the human HeLa cell model, morusin and mulberrin inhibited the phosphorylation of p70S6K1, promoted autophagy, and slowed cell senescence. The molecular docking study showed that mulberrin and morusin bind to the same pocket of p70S6K1. Collectively, our findings open up a potential class of prenylated flavones performing their antiaging activity via nutrient-sensing pathways.
- Journal
- Geroscience
- Publish Year
- 2022
- Experiment Subject
- human; human hela cell model; worm; yeast
- Experiment Type
- Cell Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Morusin and mulberrin extend the lifespans of yeast and C. elegans via suppressing nutrient-sensing pathways
- Bilingual Status
- semi_complete