ReferenceID 5519
Cellular target of isoquercetin from Passiflora ligularis Juss for glucose uptake in rat soleus muscle
Chem Biol Interact
Quercetin 3-O-beta-d-glucopyranoside (isoquercetin) is one of the most frequent metabolites of the Passiflora ligularis Juss. The purpose of this study was to investigate the effect of the aqueous extract and ethanol fra
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Record Fields
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- Reference Id
- 5519
- Evidence Id
- 22109
- Core Evidence Id
- 22109
- Source Reference Id
- 4279
- Herb2 Reference Id
- HBREF005076
- Subject Paper Key
- HBIN031102_32692981
- Pubmed Id
- 32692981
- Doi
- 10.1016/j.cbi.2020.109198
- Paper Title
- Cellular target of isoquercetin from Passiflora ligularis Juss for glucose uptake in rat soleus muscle
- Paper Abstract
- Quercetin 3-O-beta-d-glucopyranoside (isoquercetin) is one of the most frequent metabolites of the Passiflora ligularis Juss. The purpose of this study was to investigate the effect of the aqueous extract and ethanol fraction from P. ligularis Juss leaves on glycaemia and the mechanism of action of isoquercetin on glucose uptake. In the glucose tolerance test, the aqueous extract and ethanol fraction from P. ligularis Juss (125 mg/kg to 500 mg/kg o. g.) reduced glycaemia and increased the hepatic and muscular glycogen content. Phytochemical analysis evidenced the dominant presence of isoquercetin in the extract and fraction from leaves of P. ligularis Juss. Isoquercetin mediates the stimulatory effect on glucose uptake independent of insulin receptor activation but, involve PI3K, MAPK, MEK/ERK pathways and de novo protein synthesis to GLUT-4 translocation. Overall findings revealed that isoquercetin and aqueous extract and ethanol fraction of P. ligularis Juss leaves might be a promising functional food or medicine for the treatment or prevention of diabetes.
- Journal
- Chem Biol Interact
- Publish Year
- 2020
- Experiment Subject
- Experiment Type
- Animal Experiment
- Phenotype Related
- Diabetes
- Paper Title Cn
- Paper Title En
- Cellular target of isoquercetin from Passiflora ligularis Juss for glucose uptake in rat soleus muscle
- Bilingual Status
- semi_complete